亚洲免费女色在线,久久综合给合久久狠狠狠…,亚洲一区二区成人,免费人成网555www

       首頁(yè) >> 資源庫 >> 中文 >> 專(zhuān)家人才

    專(zhuān)家人才

    • 姓名: 朱強
    • 性別: 男
    • 職稱(chēng): 研究員
    • 學(xué)歷: 博士
    • 電話(huà): 020-32015287
    • 傳真: 
    • 電子郵件: zhu_qiang@gibh.ac.cn
    • 通訊地址 廣州市蘿崗區科學(xué)城開(kāi)源大道190號B區307

      簡(jiǎn)歷:

    •  朱強實(shí)驗室網(wǎng)頁(yè) 

        研究經(jīng)歷:  

        20085 至今 中國科學(xué)院廣州生物醫藥與健康研究院 PI,研究員  

        20059 20082 美國公司 XTL Biopharmaceuticals Inc. staff scientist  

        20014 20059 美國公司 Vivoquest, Inc. staff scientist 

        20008 20014月美國科羅拉多州立大學(xué)化學(xué)系博士后 

          

        教育背景: 

        19959 20006 中國科學(xué)院上海有機化學(xué)研究所博士學(xué)位 

        19919 19956 南京大學(xué)化學(xué)化工學(xué)院本科學(xué)位 

      研究領(lǐng)域:

    •   

        1C?H鍵官能化反應用于雜環(huán)化合物合成方法研究; 

        2Cu/O2 體系對有機小分子的選擇性氧化; 

        3)異腈參與的新反應研究; 

        4)藥物分子合成工藝的改進(jìn); 

        5)抗肺癌,抗肺結核藥物開(kāi)發(fā)。 

      承擔科研項目情況:

    • 1.國家自然科學(xué)基金科學(xué)部主任基金(20942001)“異腈參與的多取代喹啉的合成研究”,2009年1月至2009年12月,8萬(wàn)元,主持,已結題。

      2.廣州市科技計劃項目(2010Y1-C241)“以鄰炔基苯胺為原料合成幾類(lèi)重要的含氮雜環(huán)”,2011年1月至2011年12月,6萬(wàn)元,主持,已結題。

      3.國家自然科學(xué)基金面上項目(21072190)“通過(guò)分子內C-H鍵官能化合成幾類(lèi)雜環(huán)化合物的新方法研究”,2011年1月至2013年12月,36萬(wàn)元,主持,已結題。

      4. 2011年廣東省自然科學(xué)基金重點(diǎn)項目(S2011020000806)“銅/氧氣體系催化的烯烴脫氫氧胺化反應極其應用研究”,2011年1月至2013年12月,30萬(wàn)元,主持,已結題。

      5.中國科學(xué)院“百人計劃”(人才項目)2011年1月至2013年12月,200萬(wàn)元,主持,已結題。

      6. 國家自然科學(xué)基金面上項目(21272233)“高價(jià)碘試劑催化的氧化環(huán)化反應研究”, 2013年至2016年, 80萬(wàn)元,主持,已結題。

      7.國家自然科學(xué)基金青年基金(21202167) “銅/氧氣體系催化的烯烴脫氫氧胺化反應研究” 2013年至2015年,25萬(wàn)元,課題組成員黃金波博士主持,已結題。

      8. 廣東省自然科學(xué)基金(2014A030313796) 2015年至2017年,10萬(wàn)元,課題組成員黃金波博士主持,已結題。

      9. 中國科學(xué)院青年創(chuàng )新促進(jìn)會(huì )(人才項目) 2015年至2018年,60萬(wàn)元,課題組成員羅爽博士主持,在研。

      10. 國家自然科學(xué)基金面上項目(21472190)“鈀催化的亞胺基化環(huán)化反應用于構建雜環(huán)化合物的研究”, 2015年至2018年, 95萬(wàn)元,主持,在研。

      11.國家自然科學(xué)基金青年基金(21402203) “過(guò)渡金屬催化的雙碳氫鍵的羰基化反應” 2015年至2017年,25萬(wàn)元,課題組成員羅爽博士主持,已結題。

      12. 國家自然科學(xué)基金重點(diǎn)項目項目(21532009)“過(guò)渡金屬催化烯烴的氧化官能化新反應研究”, 2016年至2020年, 180 萬(wàn)元,參與,在研。(上海有機化學(xué)研究所劉國生研究員主持,總經(jīng)費380萬(wàn)元)

      13. 國家自然科學(xué)基金面上項目(21672215)“吲哚-2-酮-3-螺噻嗪酮類(lèi)化合物的抗結核活性研究”, 2017年至2020年, 65萬(wàn)元,課題組成員黃金波博士主持,在研。

      14.國家自然科學(xué)基金面上項目(21772198)“鈀催化的不對稱(chēng)亞胺基化反應研究”, 2018年至2021年, 64萬(wàn)元,課題組成員羅爽博士主持,在研。

      社會(huì )任職:

    •  

      獲獎及榮譽(yù):

    •   1998年,上海有機化學(xué)研究所首屆劉鑄晉獎 

        2012年,中科院廣州教育基地優(yōu)秀研究生導師 

        2012年,中科院優(yōu)秀研究生導師獎 

      代表論著(zhù):

    • 2018年
      59. Cascade double isocyanide insertion and C–N coupling of 2-iodo-2′-isocyano-1,1′-biphenyls
      Hongwei Sun, Shi Tang, Dengke Li, Yali Zhou, Jinbo Huang* and Qiang Zhu*
      Org. Biomol. Chem. 2018, 16, 3893-3896. Impact factor: 3.423

      58. PhI(OAc)2-Mediated Dearomative C–N Coupling: Facile Construction of the Spiro[indoline-3,2’-pyrrolidine] Skeleton
      Yali Zhou, Dengke Li, Shi Tang, Hongwei Sun, Jinbo Huang* and Qiang Zhu*
      Org. Biomol. Chem. 2018, 16, 2039-2042. Impact factor: 3.423
              
      57. Pd-Catalzed Divergent C(sp2)–H Activation/Cycloimidlylation of 2-Isocyano-2,3-diarylpropanoates
      Shi Tang, Sheng-Wen Yang, Hongwei Sun, Yali Zhou, Juan Li* and Qiang Zhu*
      Org. Lett. 2018, 20, 1832-1836. Impact factor:6.492

      56. Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via
      Palladium-Catalyzed Imidoylative Cyclization Reactions
      Shuang Luo,* Zhuang Xiong, Yongzhi Lu and Qiang Zhu*
      Org. Lett. 2018, 20, 1837-1840. Impact factor:6.492

      55. Stirring-Controlled Mono or Double Aminocarbonylation of 1,3-Bis(2-
      iodoaryl)propan-2-amines
      Huaanzi Hu, Zeqiang Xie, Shuang Luo* and Qiang Zhu*
      Tetrahedron Lett. 2018, 59, 1034-1037. Impact factor:2.125

      2017年
      54. Palladium-Catalyzed Imidoylative Cyclization of Tryptophan-Derived Isocyanides: Access to β-Carbolines
      Shi Tang, Jian Wang, Zhuang Xiong, Zeqiang Xie, Dengke Li, Jinbo Huang* and Qiang Zhu*
      Org. Lett. 2017, 19, 5577-5580. Impact factor:6.492.

      53. Palladium-Catalyzed C(sp2)–H Aminoimidoylation of Isocyano-Containing Arenes: Synthesis of Amino Substituted N-Heterocycles
      Zhuang Xiong, Jian Wang, Yanbo Wang, Shuang Luo* and Qiang Zhu*
      Org. Chem. Front. 2017, 4, 1768-1771. Impact factor:5.455

      52. Copper-Catalyzed Regioselective 1,2-Thioamidation of Alkenes
      Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
      Chem. Commun. 2017, 53, 3450-3453. Impact factor: 6.290

      51. A One-Pot Synthesis of [1,2,3]Triazolo[1,5-a]quinoxalines from 1-Azido-2-isocyanoarenes with High Bond-Forming E?ciency
      Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
      Chem. Commun. 2017, 53, 1305-1308. Impact factor: 6.290

      50. Palladium-Catalyzed Enantioselective C(sp2)–H lmidoylation by Desymmetrization
      Jian Wang, De-Wei Gao, Jinbo Huang, Shi Tang, Zhuang Xiong, Huaanzi Hu, Shu-Li You* and Qiang Zhu*
      ACS Catal. 2017, 7, 3832-3836. Impact factor:11.384

      49. Denitrogenative Imidoyl Radical Cyclization: Synthesis of 2 Substituted Benzoimidazoles from 1 Azido-2-isocyanoarenes
      Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
      Org. Lett. 2017, 19, 3223-3226. Impact factor:6.492

      2016年
      48. Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide
      Jian Wang, Shi Tang and Qiang Zhu*
      Org. Lett. 2016, 18, 3074-3077.

      47. Transition Metal-Free Amidoalkylation of Benzothiazoles and
      Amidoalkylarylation of Activated Alkenes with N,N-Dialkylamides
      Jian Wang, Jing Li, Jinbo Huang* and Qiang Zhu*
      J. Org. Chem. 2016, 81, 3017-3022.

      46. Pd-Catalyzed C(sp2)–H Carbonylation of 2-Benzylpyridines for the Synthesis of Pyridoisoquinolinones
      Zeqiang Xie, Shuang Luo* and Qiang Zhu*
      Chem. Commun. 2016, 52, 12873-12876.

      45. A Metal-Free Synthesis of 2-Aminobenzothiazoles through Aminyl Radical Addition to Arylisothiocyanates
      Yimiao He, Jing Li, Shuang Luo, Jinbo Huang* and Qiang Zhu*
      Chem. Commun. 2016, 52, 8444-8447.

      44. Copper-Mediated C(sp3)–H Azidation with Me3SiN3: Synthesis of Imidazoles from Ketones and Aldehydes
      Zeqiang Xie, Jiaojiao Deng, Zhiping Qiu, Juan Li* and Qiang Zhu*
      Chem. Commun. 2016, 52, 6467-6470.

      43. Dearomative C–C and C–N Bond Cleavage of 2-Arylindoles: Transition-Metal-Free Access to 2-Aminoarylphenones
      Shuang Luo,* Ziwei Hu and Qiang Zhu*
      Org. Chem. Front. 2016, 3, 364-367.

      42. Copper-Mediated C(sp3)–H Amination in a Multiple C–N Bond-Forming Strategy for the Synthesis of N-heterocycles
      Zeqiang Xie, Jiangling Peng and Qiang Zhu*
      Org. Chem. Front. 2016, 3, 82-86.

      41. Recent Progress in Imydoyl Radical-Involved Reactions
      Jian Lei, Jinbo Huang and Qiang Zhu*
      Org. Biomol. Chem. 2016, 14, 2593-2602.

      2015年
      40. Palladium-Catalyzed Intramolecular C(sp2)–H Imidoylation for the Synthesis of Six-Membered N-Heterocycles
      Jing Li, Yimiao He, Shuang Luo, Jian Lei, Jian Wang, Zeqiang Xie and Qiang Zhu*
      J. Org. Chem. 2015, 80, 2223-2230.

      39. A Facile Synthesis of Pyrazoles through Metal-Free Oxidative C(sp2)–H Cycloamination of Vinyl Hydrazones
      Dongdong Liang and Qiang Zhu*
      Asian J. Org. Chem. 2014, 4, 42-45.

      38. Copper-Catalyzed Tri?uoromethylalkynylation of Isocyanides
      Jian Lei, Xiaoxing Wu* and Qiang Zhu*
      Org. Lett. 2015, 17, 2322-2325.

      37. Copper-Catalyzed Trifluoromethylation of Trisubstituted Allylic and Homoallylic Alcohols
      Jian Lei, Xiaowu Liu, Shaolin Zhang, Shuang Jiang, Minhao Huang, Xiaoxing Wu* and Qiang Zhu*
      Chem. Eur. J. 2015, 21, 6700-6703.

      36. Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates
      Ziwei Hu, Shuang Luo* and Qiang Zhu*
      Adv. Synth. Catal. 2015, 357, 1060-1064.

      35. Palladium-Catalyzed Intermolecular C–H Amidation of Indoles with Sulfonyl Azides
      Ziwei Hu, Shuang Luo* and Qiang Zhu*
      Sci. China. Chem. 2015, 58, 1349-1353.

      34. Surface Con?ned Retro Diels-Alder Reaction Driven by the Swelling of Weak Polyelectrolytes
      Beier Lyu, Wenli Cha, Tingting Mao, Yuanzi Wu, Hujun Qian, Qiang Zhu* and Hongwei Ma*
      ACS Appl. Mater. Interfaces 2015, 7, 6254-6259.

      2014年
      33. Arylative Cyclization of 2-Isocyanobiphenyls with Anilines: One-Pot Synthesis of 6-Arylphenanthridines via Competitive Reaction Pathways
      Zhonghua Xia, Jinbo Huang, Yimiao He, Jiaji Zhao, Jian Lei and Qiang Zhu*
      Org. Lett. 2014, 16, 2546-2549.

      32. Palladium-Catalyzed C(sp2)–H Pyridocarbonylation of N-Aryl-2-aminopyridines: Dual Function of the Pyridyl Moiety
      Dongdong Liang, Yimiao He and Qiang Zhu*
      Org. Lett. 2014, 16, 2748-2751.

      31. Palladium-Catalyzed Imidoylative Cyclization of α-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles
      Jian Wang, Shuang Luo, Jinbo Huang, Tingting Mao and Qiang Zhu*
      Chem. Eur. J. 2014, 20, 11220-11224.

      30. Copper-Mediated C(sp2)–H Amination Using TMSN3 as a Nitrogen Source: Redox-Neutral Access to Primary Anilines
      Jiangling Peng, Ming Chen, Zeqiang Xie, Shuang Luo and Qiang Zhu*
      Org. Chem. Front. 2014, 1, 777-781.

      29. Copper-Catalyzed C(sp2)–H Amidation with Azides as Amino Sources
      Jiangling Peng, Zeqiang Xie, Ming Chen, Jian Wang and Qiang Zhu*
      Org. Lett. 2014, 16, 4702-4705.

      28. A Room-Temperature Synthesis of 2,2’-Bisoxazoles through Palladium-Catalyzed Oxidative Coupling of α-Isocyanoacetamides
      Jian Wang, Shuang Luo, Jing Li and Qiang Zhu*
      Org. Chem. Front. 2014, 1, 1285-1288.

      27. Copper-Catalyzed Intramolecular Oxidative C(sp3)–H Amidation of 2-Amino- acetophenones: Efficient Synthesis of Indoline-2,3-diones
      Jinbo Huang*, Tingting Mao and Qiang Zhu*
      Eur. J. Org. Chem. 2014, 2878-2882.

      2013年
      26. Synthesis of Phenanthridinones via Palladium-Catalyzed C(sp2)–H Aminocarbonylation of Unprotected o-Arylanilines
      Dongdong Liang, Ziwei Hu, Jiangling Peng, Jinbo Huang and Qiang Zhu*
      Chem. Commun. 2013, 49, 173-175.

      25. Synthesis of 10-Methylacridin-9(10H)-ones through Cu-Catalyzed Intramolecular Oxidative C(sp2)–H Amination of o-N-Methylaminobenzophenones
      Jinbo Huang, Congqing Wan, Ming-Fang Xu* and Qiang Zhu*
      Eur. J. Org. Chem. 2013, 1876-1880.

      24. C–H Cycloamination of N-Aryl-2-aminopyridines and N-Arylamidines Catalyzed by an in situ Generated Hypervalent Iodine(III) Reagent
      Yimiao He, Jinbo Huang, Dongdong Liang, Lanying Liu and Qiang Zhu*
      Chem. Commun. 2013, 49, 7352-7354.

      23. A Metal-Free Tandem Demethylenation/C(sp2)–H Cycloamination Process of N?Benzyl-2-aminopyridines via C–C and C–N Bond Cleavage
      Dongdong Liang, Yimiao He, Lanying Liu and Qiang Zhu*
      Org. Lett. 2013, 15, 3476-3479.

      22. A Transition-Metal-Free Synthesis of Arylcarboxyamides from Aryl Diazonium Salts and Isocyanides
      Zhonghua Xia and Qiang Zhu*
      Org. Lett. 2013, 15, 4110-4113.

      21. Synthesis of 1H-Indole-3-carboxamidines through a Palladium-Catalyzed Three-Component Reaction Involving Isocyanide Insertion as a Key Step
      Ziwei Hu, Jian Wang, Dongdong Liang and Qiang Zhu*
      Adv. Synth. Catal. 2013, 355, 3290-3294.

      2012 年
      20. Direct Carboxamidation of Indoles by Palladium-Catalyzed C–H Activation and Isocyanide Insertion
      Jiangling Peng, Lanying Liu, Ziwei Hu, Jinbo Huang and Qiang Zhu*
      Chem. Commun. 2012, 48, 3772-3774.

      19. Cu-Catalyzed Oxidative C(sp2)–H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans
      Jiaji Zhao, Yong Wang, Yimiao He, Lanying Liu, Qiang Zhu*
      Org. Lett. 2012, 14, 1078-1081.

      18. Cu-Catalyzed Regioselective C–H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group
      Jiaji Zhao, Yong Wang and Qiang Zhu*
      Synthesis 2012, 44, 1551-1555.

      17. Palladium(II)-Catalyzed Cycloamidination via C(sp2)–H Activation and Isocyanide Insertion
      Yong Wang and Qiang Zhu*
      Adv. Synth. Catal. 2012, 354, 1902-1908.

      16. Palladium-Catalyzed Cyclization of o-Alkynyltrifluoroacetanilides Followed by Isocyanide Insertion: Synthesis of 2-Substituted 1H-Indole-3-carboxamides
      Ziwei Hu, Dongdong Liang, Jiaji Zhao, Jinbo Huang and Qiang Zhu*
      Chem. Commun. 2012, 48, 7371-7373.

      15. Palladium-Catalyzed C(sp2)–H Cyanation Using Tertiary Amine Derived Isocyanide as a Cyano Source
      Jiangling Peng, Jiaji Zhao, Ziwei Hu, Dongdong Liang, Jinbo Huang and Qiang Zhu*
      Org. Lett. 2012, 14, 4966-4969.

      14. CuI-Mediated Sequential Iodination/Cycloetherification of o-Arylphenols: Synthesis of 2- or 4-Iododibenzofurans and Mechanistic Studies
      Jiaji Zhao, Qi Zhang, Lanying Liu, Yimiao He, Jing Li, Juan Li* and Qiang Zhu*
      Org. Lett. 2012, 14, 5362-5365.

      13. Synthesis of Benzimidazoles by PIDA-Promoted Direct C(sp2)–H Imidation of N-Arylamidines
      Jinbo Huang, Yimiao He, Yong Wang and Qiang Zhu*
      Chem. Eur. J. 2012, 18, 13964-13967.

      2011 年
      12. Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines
      Yong Wang, Honggen Wang, Jiangling Peng and Qiang Zhu*
      Org. Lett. 2011, 13, 4604-4607.

      11. Bronsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-Spiro-3,4-dihydro-2-(1H)- quinazolinones
      Honggen Wang, Jiaji Zhao, Jiancun Zhang* and Qiang Zhu*
      Adv. Synth. Catal. 2011, 353, 2653-2658.

      10. Sequential Hydration-Condensation-Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: an Efficient Approach to Quinoline-Based Heterocycles
      Lijie Peng, Honggen Wang, Changlan Peng, Ke Ding* and Qiang Zhu*
      Synthesis 2011, 1723-1732.

      9. Synthesis of Quinazolin-4(3H)-ones via Pd(II)-Catalyzed Intramolecular C(sp2)–H Carboxamidation of N-Arylamidines
      Bin Ma, Yong Wang, Jiangling Peng and Qiang Zhu*
      J. Org. Chem. 2011, 76, 6362-6366.

      8. Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles
      Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Jiancun Zhang* and Qiang Zhu*
      Angew. Chem., Int. Ed. 2011, 50, 5678-5681.

      2010 年
      7. Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted Cyclization of ortho-Alkynylaryl Isocyanides
      Jiaji Zhao, Changlan Peng, Lanying Liu, Yong Wang and Qiang Zhu*
      J. Org. Chem. 2010, 75, 7502-7504.

      6. A Direct Intramolecular C–H Amination Reaction Co-Catalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines
      Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang* and Qiang Zhu*
      J. Am. Chem. Soc. 2010, 132, 13217-13219.

      5. p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines
      Changlan Peng, Yong Wang, Lanying Liu, Honggen Wang, Jiaji Zhao and Qiang Zhu*
      Eur. J. Org. Chem. 2010, 818-822.
      4. Structure-Based Design, Synthesis and Biological Evaluation of New N-Carboxyphenylpyrrole Derivatives as HIV Fusion Inhibitors Targeting gp41
      Yong Wang, Hong Lu, Qiang Zhu*, Shibo Jiang* and Yun Liao*
      Bioorg. Med. Chem. Lett. 2010, 20, 189-192.

      2009 年
      3. An Efficient Synthesis of 4-Alkyl-2(1H)-quinazolinones and 4-Alkyl-2-chloroquinazolines from 1-(2-Alkynylphenyl)ureas
      Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang* and Qiang Zhu*
      Tetrahedron Lett. 2009, 50, 6841-6843.

      2. Tetrabutylammonium Chloride-Triggered 6-endo Cyclization of o-Alkynylisocyanobenzenes: an Efficient Synthesis of 2-Chloro-3-Substituted Quinolines
      Lanying Liu, Yong Wang, Honggen Wang, Changlan Peng, Jiaji Zhao and Qiang Zhu*
      Tetrahedron Lett. 2009, 50, 6715-6719.

      1. Sulfuric Acid Promoted Condensation Cyclization of 2-(2-(Trimethylsilyl)ethynyl)anilines with Arylaldehydes in Alcoholic Solvents: an Efficient One-Pot Synthesis of 4-Alkoxy-2-arylquinolines
      Yong Wang, Changlan Peng, Lanying Liu, Jiaji Zhao, Li Su and Qiang Zhu*
      Tetrahedron Lett. 2009, 50, 2261-2265.

      專(zhuān)利:
      1. 吳東海, 朱強, 楊松, 劉蘭英, 彭長(cháng)蘭
      青蒿素衍生物的新應用,ZL201010216620.0

      2. 朱強, 王洪根, 王勇, 梁冬冬, 劉蘭英, 張健存
      咪唑[1,2-a]吡啶和咪唑醛類(lèi)化合物的新合成方法, 專(zhuān)利號:201110110748.3

      3. 朱強, 張天宇, 劉蘭英, 魯明輝, 毛婷婷,黃金波
      吲哚[3,2-c]喹啉類(lèi)化合物或其藥學(xué)上可接受的鹽及其制備方法和應用, 中國專(zhuān)利號:201310385431.X

      4. 涂正超,朱強,張天宇,黃金波,徐曉冰,萬(wàn)軍庭,黎敏科,李登科,周亞麗,劉志永,王邦興,米琦.托特雷拉
      吲哚-2-酮-3-螺噻嗪或噻唑酮化合物及其應用,中國專(zhuān)利號:CN201610657161.7