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       首頁(yè) >> 資源庫 >> 中文 >> 專(zhuān)家人才
    
                
    

                
    專(zhuān)家人才
    

                
    
                    
    
                        
      
                            
    • 姓名： 劉勁松
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    • 性別： 男
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    • 職稱(chēng)： 研究員
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    • 學(xué)歷： 博士
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    • 電話(huà)： 
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    • 傳真： 
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    • 電子郵件: liu_jinsong@gibh.ac.cn
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    • 通訊地址 廣州蘿崗區科學(xué)城開(kāi)源大道190號
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      簡(jiǎn)歷：
      
                            
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      1988-6/1992 北京大學(xué) 學(xué)士
       
 
      1994-1/2000 美國羅格斯大學(xué) (Rutgers University) 博士
       
 
      2000 - 2/2000 美國羅格斯大學(xué) (Rutgers University) 博士后
       
 
      2000 - 8/2004 美國 Tularik 公司，科學(xué)家 , 助理科學(xué)家 , 資深研究助理
       
 
      2004 - 10/2005 美國 Amgen 公司，資深科學(xué)家
       
 
      2005 - 現在 中國科學(xué)院廣州生物醫藥與健康研究院，研究員
       

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      研究領(lǐng)域：
      
                            
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      以結構生物學(xué)為主要手段，緊密結合新藥研發(fā)，著(zhù)眼于與人類(lèi)重大疾病和重要生理功能相關(guān)的蛋白質(zhì)及其復合體的結構與功能的關(guān)系，闡明生物大分子與小分子化合物在結構與功能方面的分子作用機理，為藥物的分子設計提供思路；同時(shí)，通過(guò)解析生物大分子及其復合物的三維結構，為藥物設計提供一個(gè)分子水平上的模板 。
       

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      承擔科研項目情況：
      
                            
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      1. 國家重點(diǎn)研發(fā)計劃（2017年），項目負責人。
       
 
      2. 973（2012年，2005年），項目負責人。
       
 
      3. 國家自然科學(xué)基金面上項目（2018年、2016年、2012年、2009年），項目負責人。
       
 
      4. 國家自然科學(xué)基金聯(lián)合基金項目（2013年），項目負責人。
       
 
      5. 廣東省自然科學(xué)基金團隊項目（2015），項目負責人。
       
 
      6. 廣州市健康醫療協(xié)同創(chuàng  )新重大專(zhuān)項（2014），項目負責人。
       

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      社會(huì )任職：
      
                            
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      呼吸疾病國家重點(diǎn)實(shí)驗室  副主任
       
 
      廣東省生物醫藥計算重點(diǎn)實(shí)驗室 副主任
       

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      獲獎及榮譽(yù)：
      
                            
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      代表論著(zhù)：
      
                            
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       1.    Xu T.*, Gan Q., Wu B., Yin M., Xu J., Shu X.,Liu J.*. Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. J Mol Biol 2020, 432(16): 4750-4761.
       
      2.     Xu J.#*, Tang X.#, Zhu Y., Yu Z., Su K., Zhang Y., Dong Y., Zhu W., Zhang C., Wu R., Liu J.*. Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition. Commun Biol 2020, 3(1): 455. 
       
      3.    Makafe, G. G.#, Hussain, M.#, Surineni, G., Tan, Y., Wong, N. K., Julius, M., Liu, L., Gift, C., Jiang, H., Tang, Y., Liu, J., Tan, S., Yu, Z., Liu, Z., Lu, Z., Fang, C., Zhou, Y., Zhang, J., Zhu, Q., Liu, J.* and Zhang, T.* Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase. Cell Chem Biol 2019, 26, 1187-1194 e1185 
       
      4.     Hussain, M.#, Adah, D.#, Tariq, M., Lu, Y., Zhang, J.* and Liu, J.* CXCL13/CXCR5 signaling axis in cancer. Life Sci 2019, 227, 175-186
       
      5.     Xu T, Zhou CZ, Xiao J.*, Liu J.* Unique Conformation in a Natural Interruption Sequence of Type XIX Collagen Revealed by Its High-Resolution Crystal Structure. Biochemistry 2018, 57(7): 1087-1095
       
      6.     Wang N, Zou Q, Xu J, Zhang J, Liu J.* Ligand binding and heterodimerization with retinoid X receptor alpha (RXRalpha) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding. The Journal of biological chemistry 2018, 293(47): 18180-18191
       
      7.     Xu T., Xie C., Yao D., Zhou CZ., Liu J.*. Crystal structures of Aflatoxin-oxidase from Armillariella tabescens reveal a dual activity enzyme. Biochemical and biophysical research communications 2017, 494(3-4): 621-625
       
      8.     Xu J#, Zhang L#, Ye Y, Shan Y, Wan C, Wang J, Pei D, Shu X.*, Liu J.* SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure 2017, 25(8): 1251-1263 e1255
       
      9.     Hou S, Xu T, Xu J, Qu L, Xu Y, Chen L, Liu J*. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE. Scientific reports 2017, 7(1): 10815
       
      10.   Zhu Y#, Xu J#, Mei X#, Feng Z, Zhang L, Zhang Q, Zhang G, Zhu W*, Liu J*, Zhang C*. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS chemical biology 2016, 11(4): 943-952
       
      11.   Hussain M, Lu Y, Liu YQ, Su K, Zhang J, Liu J*, Zhou GB*. Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery. Pharmacological research 2016, 111: 34-42
       
      12.   Zhu L, Yang J, Li H, Sun H, Liu J*, Wang J*. Conformational change study of dengue virus NS2B-NS3 protease using (19)F NMR spectroscopy. Biochemical and biophysical research communications 2015, 461(4): 677-680
       
      13.  Liu YQ#, Wang XL#, Cheng X#, Lu YZ#, Wang GZ#, Li XC, Zhang J, Wen ZS, Huang ZL, Gao QL, Yang LN, Cheng YX*, Tao SC, Liu J *, Zhou GB*. Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget 2015, 6(33): 34953-34967
       
      14.   Guo S#, Xu J#, Pavlidis IV, Lan D, Bornscheuer UT, Liu J*, Wang Y*. Structure of product-bound SMG1 lipase: active site gating implications. The FEBS journal 2015, 282(23), 4538-4547
       
      15.   Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J*. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins 2014, 82(12): 3483-3489
       
      16.   Mei G, Dong J, Li Z, Liu S, Liu Y, Sun M, Liu G, Su Z*, Liu J*. Structural basis for the immunomodulatory function of cysteine protease inhibitor from human roundworm Ascaris lumbricoides. PloS one 2014, 9(4): e96069
       
      17.   Li H, Zhu L, Hou S, Yang J, Wang J*, Liu J*. An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease. FEBS letters 2014, 588(17): 2794-2799
       
      18.   Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J*. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. The Journal of biological chemistry 2013, 288(23): 16598-16605
       
      19.   Xu T#, Liu L#, Hou S, Xu J, Yang B, Wang Y*, Liu J*. Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity. J Struct Biol 2012, 178(3): 363-369
       
      20.  Liu J#, Sudom A#, Min X#, Cao Z, Gao X, Ayres M, Lee F, Cao P, Johnstone S, Plotnikova O, Walker N, Chen G, Wang Z. Structure of the nuclear factor kappaB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. The Journal of biological chemistry 2012, 287(33): 27326-27334
       
      21.   Bi Y, Zhu L, Li H, Wu B, Liu J*, Wang J*. Backbone (1)H, (13)C and (15)N resonance assignments of dengue virus NS2B-NS3p in complex with aprotinin. Biomol NMR Assign 2012, 7:137-139
       
      22.   Zhang Y, Xu T, Chen Q, Wang B, Liu J*. Expression, purification, and refolding of active human and mouse secreted group IIE phospholipase A. Protein Expr Purif 2011, 80(1): 68-73
       
      23.   Wang Y, Wang Q, Zhu Q, Zhou R, Liu J*, Peng T*. Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children. J Clin Virol 2011, 52(2): 107-112
       
      24.   Lu N, Wang W, Liu J*, Wong CW*. Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha. Cell Signal 2011, 23(9): 1473-1478
       
      25.   Liu S, Dong J, Mei G, Liu G, Xu W, Su Z, Liu J*. Crystallization and preliminary crystallographic studies of a cysteine protease inhibitor from the human nematode parasite Ascaris lumbricoides. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011, 67(Pt 2): 228-230
       
      26.   Liu Q, Shen Y, Liu S, Weng J, Liu J*. Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site. FEBS letters 2011, 585(8): 1175-1179
       
      27.   Gong L, Xiao Y, Liu Q, Li S, Zhang C, Liu J*. Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011, 67(Pt 1): 136-139
       
      28.   Gao M#, Wang J#, Lu N#, Fang F, Liu J*, Wong CW*. Mitogen-activated protein kinase kinases promote mitochondrial biogenesis in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression. Biochimica et biophysica acta 2011, 1813(6): 1239-1244
       
      29.   Xu W#, Yi L#, Feng Y, Chen L*, Liu J*. Structural insight into the activation mechanism of human pancreatic prophospholipase A2. The Journal of biological chemistry 2009, 284(24): 16659-16666. 
       
      30. Bella J#, Liu J#, Kramer R, Brodsky B, Berman HM*. Conformational effects of gly-x-gly interruptions in the collagen triple helix. J Mol Biol 2006, 362(2): 298-311.
       
      30.   Wang Z#, Benoit G#, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP*, Perlmann T*. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 2003, 423(6939): 555-560.
       
      31.   Benoff B, Yang H, Lawson CL, Parkinson G, Liu J, Blatter E, Ebright YW, Berman HM*, Ebright RH*. Structural basis of transcription activation: the CAP-alpha CTD-DNA complex. Science 2002, 297(5586): 1562-1566.
       
      32.   Liu J, Lynch PA, Chien CY, Montelione GT, Krug RM, Berman HM*. Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol 1997, 4(11): 896-899.
       
       
             
 
       

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