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• 1988-1994       學(xué)士學(xué)位， 醫學(xué)與外科學(xué)專(zhuān)業(yè)                       納瓦拉大學(xué) （Pamplona, 西班牙） 
  1999-2003       博士學(xué)位， 生物化學(xué)與分子生物學(xué)專(zhuān)業(yè)       馬德里自治大學(xué) （西班牙） 
  
  
• 1991-1992       納瓦拉大學(xué)病理學(xué)系，研究助理
  1992-1993       納瓦拉大學(xué)微生物學(xué)系，研究助理（納瓦拉大學(xué)是西班牙最知名的醫科類(lèi)大學(xué)）
  1995-1998       免疫學(xué)臨床專(zhuān)業(yè)資格 (需通過(guò)國家水平考試)公主醫院 （馬德里，西班牙）急癥科夜間輪值醫生
  2004-2007       倫敦帝國學(xué)院醫學(xué)部腎臟實(shí)驗室，副研究員（主任：Patrick Maxwell教授）
  2007年12月    加入廣州生物醫藥與健康研究院，從事腫瘤干細胞研究 

• Metabolism and cell cycle control in embryonic stem cells.
• Molecular pathways underlying the generation of induced pluripotent stem (iPS) cells from somatic cells.
• Effects of altered oxygenation (hypoxia) on embryonic and cancer stem cell behavior.

• 博士前獎學(xué)金BEFI獎(2001), 卡洛斯三世衛生機構
• 博士前獎學(xué)金FPI獎(1999)， 馬德里自治區
• 短期訪(fǎng)問(wèn)研究獎(2002) ， 卡洛斯三世衛生機構(倫敦帝國學(xué)院，腎臟實(shí)驗室，為期6個(gè)月的訪(fǎng)問(wèn)研究) 
• 訪(fǎng)問(wèn)研究獎(2003)), Wellcome Trust基金會(huì )，獎金金額超過(guò)￡90,000； 項目名稱(chēng): ‘Enzyme-substrate interactions underlying the hydroxylation of Hypoxia-Inducible Factor by oxygen dependent-dioxygenases’
• 英國一聯(lián)合癌癥研究項目負責人之一（2004），項目經(jīng)費超過(guò)￡50,000；項目名稱(chēng): ‘Role of the von Hippel-Lindau tumour suppressor in regulating intercellular adhesion’ 
• 英國一聯(lián)合癌癥研究項目負責人之一（2006），項目經(jīng)費超過(guò)￡100,000；項目名稱(chēng): ‘Role of Hypoxia-Inducible Factor in controlling epithelial-to-mesenchymal transitions’

　　* Corresponding author 

　　1- Sarah K. Harten, Deepa Shukla, Ravi Barod, Alexander Hergovich, Maria Balda, Karl Matter, and Esteban MA* and Patrick H. Maxwell. Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin. Molecular Biology of the Cell 2009. 20: 1089-1101.  　  

　　2- Esteban MA, Xu J, Yang J, Peng M, Qin D, Li W, Jiang Z, Chen J, Deng K, Zhong M, Cai J, Lai L, Pei D. Generation of induced pluripotent stem cell lines from Tibetan miniature pig. Journal of Biological Chemistry 2009. 284: 17634-40.    

　　3- Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell 2010. 6(1): 71-79.  Cover story, most read article of the month in Cell Stem Cell after 4 days of publication online   

　　4- Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B, Xu J, Li W, Yang J, Gan Y, Qin D, Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA*, Pei D. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010. 7 (1): 51-63. Among top ten scientific articles of the year in China   

　　5- Xu J, Li H, Wang B, Xu Y, Yang J, Zhang X, Harten SK, Shukla D, Maxwell PH, Pei D, Esteban MA*. VHL Inactivation Induces HEF1 and Aurora Kinase A. Journal of the American Society of Nephrology 2010. 21(12): 2041-2046.     

　　6- Yang J, Cai J, Zhang Y, Wang X, Li W, Xu J, Li F, Guo X, Deng K, Zhong M, Chen Y, Lai L, Pei D, Esteban MA*. Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. Journal of Biological Chemistry 2010. 285(51): 40303-11.    

　　7- Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo X, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So KF, Redl H, Zeng L, Esteban MA*, Pei D. Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. Journal of Biological Chemistry 2010. 285(15):11227-34.    

　　8- Ho JC, Zhou T, Lai WH, Huang Y, Chan YC, Li X, Wong NL, Li Y, Au KW, Guo D, Xu J, Siu CW, Pei D, Tse HF, Esteban MA*. Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C. AGING 2011. 22(7): 1221-8. 　  

　　9- Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA*, Pei D.Microrna cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. Journal of Biological Chemistry 2011. 286(19): 17359-64.  　  

　　10- Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, Wang Y, Zhang Y, Zhuang Q, Li Y, Bao X, Tse HF, Grillari J, Grillari-Voglauer R, Pei D, Esteban MA*. Generation of human induced pluripotent stem cells from urine. Journal of the American Society of Nephrology 2011. 22(7): 1221-8.    

　　11- Zhang S, Chen S, Li W, Guo X, Zhao P, Xu J, Chen Y, Pan Q, Liu X, Zychlinski D, Lu H, Tortorella MD, Schambach A, Wang Y, Pei D, Esteban MA*. Rescue of ATP7B function in hepatocyte-like cells from Wilson’s disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Human molecular genetics 2011. 20(16): 3176-87.    

　　12-J Xu, B Wang, Y Xu, L Sun, W Tian, D Shukla, R Barod, J Grillari, R Grillari-Voglauer, PH Maxwell andEsteban MA*. Epigenetic regulation of HIF-1a in renal cancer cells involves HIF-1a/2a binding to a reverse hypoxia-response element. Oncogene 2011.31(8):1065-72. 　  

　　13- Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, Qin B, Zeng L, Esteban MA, Pan G, Pei D. Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin C Dependent Manner. Cell Stem Cell 2011. 9(6): 575-587. 　  

　　14- Li W, Wang X, Fan W, Zhao P, Chan YC, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng KM, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse HF, Pei D, Esteban MA*. Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes. Human molecular genetics 2012. 21(1): 32-35. 　  

　　15- Esteban MA*, Pei D. Vitamin C improves the quality of somatic cell reprogramming. Nature Genetics 2012.44(4):36-7.  

　　16- Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, Wang Y, Zhang Y, Zhuang Q, Li Y, Bao X, Tse HF, Grillari J, Grillari-Voglauer R, Pei D, Esteban MA*. A protocol for generating human induced pluripotent stem cells from urine samples. Nature protocol 2012.10:2080-9   

　　17- Esteban MA, Bao X, Zhuang Q, Qin B, Pei D. The mesenchymal-to-epithelial transition in somatic cell reprogramming. Current Opinion in Genetics & Development 2012. 22(5):423-8.   

　　18- Tian W, Cui F, Esteban MA*. E2F1 in renal cancer: Mr Hyde disguised as Dr Jekyll?Journal of Pathology 2013. 231: 143–146  

　　19- Zhuang Q, Qing X, Ying Y, Wu H, Benda C, Lin J, Huang Z, Liu L, Xu Y, Bao X, Qin B, Pei D, Esteban MA*. Class IIa histone deacetylases and myocyte enhancer factor 2 proteins regulate the mesenchymal-to-epithelial transition of somatic cell reprogramming. Journal of Biological Chemistry 2013. 288(17) 12022-31.   

　　20- Bao X, Zhu X, Liao B, Benda C, Zhuang Q, Pei D, Qin B, Esteban MA*. MicroRNAs in somatic cell reprogramming. Current Opinion in Cell Biology 2013. 25(2):208-14.   

　　21- Xu Y, Liu L, Laslett AL, Esteban MA *. Cell Reprogramming: into the groove. Nature Materials. 2013. 12:1082-1084.  (News and Views)  

　　22- Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung TL, Laslett AL, Willam C, Qin B, Maxwell PH, Esteban MA *. Hypoxia-Inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-Induced Toxicity. Journal of Biological Chemistry 2014. 289(6): 3339-51.   

　　23- Wang Y, Fan N, Tian W, Cui F, Newsome PN, Frampton J, Esteban MA* and Lai L.  Generation of knockout rabbits using transcription activator-like effect or nucleases. Cell Regeneration 2014. 3:3