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專(zhuān)家人才
- 姓名： 吳東海
- 性別： 男
- 職稱(chēng)： 研究員
- 學(xué)歷： 博士
- 電話(huà)：
- 傳真：
- 電子郵件: wu_donghai@gibh.ac.cn
- 通訊地址 廣州蘿崗區科學(xué)城開(kāi)源大道190號
- 1980 – 1984 北京師范大學(xué)生物系學(xué)士
1985 – 1990 美國德州西南醫學(xué)中心生物化學(xué)與分子生物學(xué)博士
- 1990 – 1992 美國德州西南醫學(xué)中心生物化學(xué)系，博士后
1992 – 1994 美國肯塔基大學(xué)生物化學(xué)系，助理研究教授
1994 – 1998 美國肯塔基大學(xué)生物化學(xué)系，助理教授
1998 – 2004 美國佛羅里達大學(xué)藥學(xué)院藥物化學(xué)系，助理教授
2004 – 至今 中國科學(xué)院廣州生物醫藥與健康研究院，研究員
- 1980 – 1984 北京師范大學(xué)生物系學(xué)士
簡(jiǎn)歷：
研究領(lǐng)域：
- 2004CB720102 973計劃 與疾病相關(guān)抗體的結構與功能研究
- 30670457 國家自然科學(xué)基金 肉堿棕櫚酰轉移酶1c的功能研究
- 30710527 國家自然科學(xué)基金國際合作項目 肉堿棕櫚酰轉移酶1c對脂肪細胞因子的調控研究
- 30810099 國家自然科學(xué)基金國際合作項目 APPL1介導脂聯(lián)素心臟保護作用的功能研究
- 2007Z2-E4021 廣州市科技計劃 CPT1-A轉基因小鼠的構建和代謝疾病研究
- 中國科學(xué)院院地合作項目 廣東省生物醫藥產(chǎn)業(yè)發(fā)展瓶頸與對策研究
承擔科研項目情況：
社會(huì )任職：
獲獎及榮譽(yù)：
- L. Mao, W. Lin, T. Nie, X. Hui, X. Gao, K. Li, M. Ding, X. Tang, P. Li, Y. Wang, A. Xu, P. Liu, and D. Wu (2014). Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci 4, 60.
- K. K. Cheng, W. Zhu, B. Chen, Y. Wang, D. Wu, G. Sweeney, B. Wang, K. S. Lam, and A. Xu (2014). The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes.
- X. Li, L. Wang, X. E. Zhou, J. Ke, P. W. de Waal, X. Gu, M. H. Tan, D. Wang, D. Wu, H. E. Xu, and K. Melcher (2014). Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res.
- Song Yang, Ye Kuang, Hongbo Li, Yuehong Liu, Xiaoyan Hui, Peng Li, Zhiwu Jiang, Yulai Zhou, Yu Wang, Aimin Xu, Shiwu Li, Pentao Liu, and Donghai Wu (2013). Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1' site. Plos One 8.
- Nie, T., Hui, X., Gao, X., Li, K., Lin, W., Xiang, X., Ding, M., Kuang, Y., Xu, A., Fei, J., et al. (2012). Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. FEBS Lett.
- Lin, W., Huang, X., Zhang, L., Chen, D., Wang, D., Peng, Q., Xu, L., Li, J., Liu, X., Li, K., et al. (2012). BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase. PLoS One 7, e44570.
- Bai, B., Liang, Y., Xu, C., Lee, M.Y., Xu, A., Wu, D., Vanhoutte, P.M., and Wang, Y. (2012). Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation 126, 729-740.
- Gao, S., Zhu, G., Gao, X., Wu, D., Carrasco, P., Casals, N., Hegardt, F.G., Moran, T.H., and Lopaschuk, G.D. (2011). Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A 108, 9691-9696.
- Gao, X., Li, K., Hui, X., Kong, X., Sweeney, G., Wang, Y., Xu, A., Teng, M., Liu, P., and Wu, D. (2011). Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. Biochem J 435, 723-732.
- Hui, X., Li, H., Zhou, Z., Lam, K.S., Xiao, Y., Wu, D., Ding, K., Wang, Y., Vanhoutte, P.M., and Xu, A. (2010). Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem 285, 10273-10280.
- Wen, L., Liu, J., Chen, Y., and Wu, D. (2010). Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis. Biochem Biophys Res Commun 396, 419-424.
- Zhou, M., Xu, A., Lam, K.S., Tam, P.K., Che, C.M., Chan, L., Lee, I.K., Wu, D., and Wang, Y. (2010). Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. J Hepatol 53, 1108-1116.
- Gao, Y., Zhou, Y., Xu, A., and Wu, D. (2008). Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells. Biol Pharm Bull 31, 1716-1722.
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