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       首頁(yè) >> 資源庫 >> 中文 >> 專(zhuān)家人才
    
                
    

                
    專(zhuān)家人才
    

                
    
                    
    
                        
      
                            
    • 姓名： 劉興國
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    • 性別： 男
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    • 職稱(chēng)： 研究員
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    • 學(xué)歷： 博士
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    • 電話(huà)： 
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    • 傳真： 
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    • 電子郵件: liu_xingguo@gibh.ac.cn
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    • 通訊地址 廣州市開(kāi)源大道190號
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      簡(jiǎn)歷：
      
                            
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      2002年-2006年：清華大學(xué)生物科學(xué)與技術(shù)系，博士
      

      1998年-2002年：山東大學(xué)生命科學(xué)學(xué)院，學(xué)士
      

      2007年-2010年: Thomas Jefferson University, 博士后
      

      2010年－至今： 中國科學(xué)院廣州生物醫藥與健康研究院 研究員
      

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      研究領(lǐng)域：
      
                            
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      ·干細胞命運調控中的核與線(xiàn)粒體等細胞器重塑
      

      ·人類(lèi)線(xiàn)粒體疾病的病理與干細胞治療
      

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      承擔科研項目情況：
      
                            
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      社會(huì )任職：
      
                            
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      “Science Bulletin（《科學(xué)通報》英文版）執行編委 
      

      亞洲線(xiàn)粒體研究與醫學(xué)學(xué)會(huì )  常務(wù)理事 
      

      中國生物物理學(xué)會(huì ) 常務(wù)理事 
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      獲獎及榮譽(yù)：
      
                            
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      ·國家自然科學(xué)“杰出青年“基金 
      

      ·國家重點(diǎn)研發(fā)計劃首席科學(xué)家
      

      ·廣東省科學(xué)技術(shù)獎自然科學(xué)一等獎（第一完成人）
      

      ·樹(shù)蘭醫學(xué)青年獎
      

      ·國家自然科學(xué)優(yōu)秀青年基金
      

      ·長(cháng)江學(xué)者獎勵計劃青年學(xué)者
      

      ·2016年干細胞青年研究員獎
      

      ·廣東省特支計劃－科技創(chuàng  )新“領(lǐng)軍人才”
      

      ·廣東省自然科學(xué)杰出青年基金獲得者（首屆）
      

      ·國際生物物理學(xué)會(huì ) "2011 Young Bioenergeticist award"
      

      ·中國科學(xué)院廣州教育基地優(yōu)秀研究生導師
      

      ·中國科學(xué)院廣州分院優(yōu)秀青年科學(xué)家
      

      ·臻溪生命科學(xué)優(yōu)秀教育工作者獎教金
      

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      代表論著(zhù)：
      
                            
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      1.     Ying, Z., Xiang G., Zheng, L., …Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 28(6):935-945.
      

      2.     Ying, Z., Chen K., Zheng, L., …Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1):220-226.
      

      3.     Li, L., Chen, K., Wang, T., …Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2(9):882-892.
      

      4.     Long, Q., Zhou, Y., Wu, H., …Liu, X*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nature Structural & Molecular Biology 28(11):900-908.
      

      5.     Li, W., Long, Q., Wu, H., …Liu, X*. (2022). Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nature Communications, 2022 Dec 2;13(1):7414. doi: 10.1038/s41467-022-35199-0
      

      6.     Bao, F., Zhou, L., Zhou, R., …Tian, M*&Liu, X*. (2022). Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances, 8(15):eabk2376.
      

      7.     Wu, Y., Chen, K., Xing, G., …Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances, 5(11):eaax7525.
      

      8.     Guo, J., Duan, L., He, X., …Liu, X*. (2021). A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome. Advanced Science 8(10):2004680. (封面)
      

      9.     Li, S., Guo, J., Ying, Z., ... Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5):1730-1739. 
      

      10. Chen, K., Long, Q., Xing, G., …Pei, D*& Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal, 39(1):e99165 (F1000推薦)
      

      11. Xiang, G., Yang, L., Long, Q., …Liu, X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy, 13(9):1543-1555.
      

      12. Zhou, Y., Long, Q., Wu, H., …Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy, 16(3):562-574. (封面)
      

      13. Wu, Y., Chen, K., Li L., …Liu, X*. (2022). Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death & Differentiation, 29(11):2316-2331.
      

      14. Xing, G., Liu, Z., Huang L., …Pei, D* Liu, X* & Chen, K*. (2022). MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death & Differentiation, 29(5):1042-1054.
      

      15. Yang, L., Lin, X., Tang, H.,....Liu, X*. (2020).  Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell 19(9):e13206.
      

      16. Yao, D., Li, Y., Zeng, S., …Liu, X*. (2022). Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space. Science China-Life Sciences, 65(2):227-235. (封面).
      

      17. Bao, F., Shi, H., Gao, M.,…Liu, X*. (2018). Polybrene induces neural degeneration by bidirectional Ca2+ influx dependent mitochondrial and ER-mitochondrial dynamics. Cell Death & Disease, 9(10):966.
      

      18. Li, L., Chen, K., Wu Y.,...Liu, X*. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death & Disease, 8(10):e3107.
      

      19. Lin, Y., Xiao, M., Chen, H., Meng, Y., Zhao, N., Yang, L., Tang, H., Wang, J., Liu, X*, Zhu, Y.*, Zhuang, S.*. (2019). A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death & Disease, 10(7):528
      

      20. Yang, L., Long, Q., Liu, J., ... Liu, X*. (2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA. Cellular and Molecular Life Sciences, 72(13):2585-2598. 
      

      21. Chen, K., Long, Q., Wang, T., … Liu, X* & Pei, D*. (2016). Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Reports,17(11): 1641-1656.
      

      22. Bao, F., Shi, H., Long, Q., …Liu, X*. (2016). Mitochondrial membrane potential-dependent endoplasmic reticulum fragmentation is an important step in neuritic degeneration. CNS Neuroscience & Therapeutics, 22(8):648-660.  (封面)
      

      23. Yang, L., Tang, H., Lin, X....Liu, X*. (2020). OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. Frontiers in Cell and Developmental Biology, 8: 180.
      

      24. Wu, Y., Chen, K., Liu, X., ... Liu, X*. (2015). Srebp‐1 Interacts with c‐Myc to Enhance Somatic Cell Reprogramming. Stem Cells, 34(1): 83-92. 
      

      25. Long, Q., Zhao, D., Fan, W., ... Wang X* & Liu, X*. (2015). Modeling of mitochondrial donut formation. Biophysical Journal, 109(5):892-899.
      

      26. Liu, W., Long, Q., Chen, K., ... & Liu, X*. (2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation. Biochemical and Biophysical Research Communications, 431(4), 767-771.
      

      27. Liu, X., Weaver, D., Shirihai, O., & Hajnóczky, G. (2009). Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics. The EMBO Journal, 28(20), 3074-3089. (F1000推薦)
      

      28. Liu, X., & Hajnoczky, G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress. Cell Death & Differentiation, 18(10), 1561-1572. (F1000推薦)
      

      29. Weaver, D., Eisner, V., Liu, X., … & Hajnóczky, G. (2014). Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. Molecular Cell, 54(5), 870-878. (co-first author)
      

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