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       首頁(yè) >> 資源庫 >> 中文 >> 專(zhuān)家人才
    
                
    

                
    專(zhuān)家人才
    

                
    
                    
    
                        
      
                            
    • 姓名： 鄭輝
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    • 性別： 男
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    • 職稱(chēng)： 研究員
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    • 學(xué)歷： 博士
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    • 電話(huà)： 
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    • 傳真： 
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    • 電子郵件: zheng_hui@gibh.ac.cn
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    • 通訊地址 廣州市開(kāi)源大道190號
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      簡(jiǎn)歷：
      
                            
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      2001-2005清華大學(xué)生物科學(xué)與技術(shù)系學(xué)士學(xué)位 
      

      2005-2010美國明尼蘇達大學(xué)藥理系博士學(xué)位 
      

      


      2010-2010美國明尼蘇達大學(xué)藥理系博士后 
      

      2010-至今中國科學(xué)院廣州生物醫藥與健康研究院研究員 
      

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      研究領(lǐng)域：
      
                            
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      1. 細胞命運轉換（分化，去分化，轉分化）的機制研究 
      

      2. 神經(jīng)干細胞介導的學(xué)習和記憶 
      
3. 嗎啡受體的信號通路和成癮性研究
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      承擔科研項目情況：
      
                            
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      社會(huì )任職：
      
                            
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      獲獎及榮譽(yù)：
      
                            
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      代表論著(zhù)：
      
                            
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      　　*代表通訊作者 
      

      　　第一作者或者通訊作者論文 
      

      　　01) Zheng H, Hutchins AP, Pan G, Li Y, Pei D*, & Pei G* Where cell fate conversions meet Chinese philosophy. Cell Res (2014) 24(10):1162-3. 
      

      　　02) Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, & Zheng H* Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms. Biol Psychiatry (2014) 76(10):775-84. 
      

      　　03) Li X, Pei D, & Zheng H* Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell (2014) 5(8):580-91. 
      

      　　04) Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D*, & Zheng H* Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol (2013) 15(7):829-838. 
      

      　　05) Zheng H*, Zhang Y, Li W, Loh HH, & Law PY NeuroD Modulates Opioid Agonist-Selective Regulation of Adult Neurogenesis and Contextual Memory Extinction. Neuropsychopharmacology (2013) 38(5):770-777. 
      

      　　06) Zheng H*, Loh HH, & Law PY Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods Enzymol (2013) 522:391-408. 
      

      　　07) Zheng H*, Zou H, Liu X, Chu J, Zhou Y, Loh HH, & Law PY Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. J Lipid Res (2012) 53(6):1153-1162. 
      

      　　08) Zheng H*, Pearsall EA, Hurst DP, Zhang Y, Chu J, Zhou Y, Reggio PH, Loh HH, & Law PY Palmitoylation and membrane cholesterol stabilize mu-opioid receptor homodimerization and G protein coupling. BMC Cell Biol (2012) 13:6. 
      

      　　09) Zheng H*, Law PY, & Loh HH Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Front Genet (2012) 3:113. 
      

      　　10) Zheng H*, Chu J, Zhang Y, Loh HH, & Law PY Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. J Biol Chem (2011) 286(14):12724-12733. 
      

      　　11) Zheng H*, Zeng Y, Zhang X, Chu J, Loh HH, & Law PY mu-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD. Mol Pharmacol (2010) 77(1):102-109. 
      

      　　12) Zheng H*, Zeng Y, Chu J, Kam AY, Loh HH, & Law PY Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. J Neurosci (2010) 30(24):8102-8110. 
      

      　　13) Zheng H*, Loh HH, & Law PY Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications. IUBMB Life (2010) 62(2):112-119. 
      

      　　14) Zheng H*, Chu J, Zeng Y, Loh HH, & Law PY Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. J Biol Chem (2010) 285(29):21994-22002. 
      

      　　15) Zheng H*, Loh HH, & Law PY beta-Arrestin-Dependent mu-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Mol Pharmacol (2008) 73(1):178-190. 
      

      　　16) Zheng H*, Chu J, Qiu Y, Loh HH, & Law PY Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc Natl Acad Sci U S A (2008) 105(27):9421-9426. 
      

      　　  
      

      　　其他論文 
      

      　　01) Xu C*, Zhang Y, Zheng H, Loh HH, & Law PY Morphine modulates mouse hippocampal progenitor cell lineages by up-regulating miR-181a level. Stem Cells (2014) 32(11):2961-72. 
      

      　　02) Wu Q*, Hwang CK, Zheng H, Wagley Y, Lin HY, Kim do K, Law PY, Loh HH, & Wei LN MicroRNA 339 down-regulates mu-opioid receptor at the post-transcriptional level in response to opioid treatment. FASEB J (2013) 27(2):522-535. 
      

      　　03) Chu J*, Zheng H, Zhang Y, Loh HH, & Law PY Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization. Cell Signal (2010) 22(4):684-696. 
      

      　　04) Chu J*, Zheng H, Loh HH, & Law PY Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cell Signal (2008) 20(9):1616-1624. 
      

      　　05) Pan G, Li J, Zhou Y, Zheng H, & Pei D* A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J (2006) 20(10):1730-1732. 
      

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