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專(zhuān)家人才
- 姓名: 秦寶明
- 性別: 男
- 職稱(chēng): 研究員
- 學(xué)歷: 博士
- 電話(huà):
- 傳真:
- 電子郵件: qin_baoming@gibh.ac.cn
- 通訊地址 廣州市開(kāi)源大道190號
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教育:2007.9-2010.6,博士,細胞生物學(xué),中國科學(xué)院廣州生物醫藥與健康研究院1994.9-1998.6,學(xué)士,生物化學(xué)與分子生物學(xué),北京大學(xué)生命科學(xué)學(xué)院工作:2013.9-現在,研究員,中科院廣州生物醫藥與健康研究院2010.7-2013.8,副研究員,中科院廣州生物醫藥與健康研究院2004.9-2007.8,助理研究員,中科院廣州生物醫藥與健康研究院
簡(jiǎn)歷:
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代謝與細胞命運實(shí)驗室:
衰老主要通路mTORC1-線(xiàn)粒體在干細胞穩態(tài)維持和命運決定中的作用和機制;
胚胎發(fā)育早期不同命運干細胞的轉錄和表觀(guān)遺傳調控機理。
研究領(lǐng)域:
承擔科研項目情況:
社會(huì )任職:
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2019年,廣東省自然科學(xué)一等獎“尿液誘導多能干細胞技術(shù)及體細胞重編程機制”(第二完成人);廣州開(kāi)發(fā)區“黃埔人才”;
2017,中國科學(xué)院杰出科技成就獎“干細胞多能性與重編程機理研究集體”(主要完成人);
2016,廣東省“特支計劃”科技創(chuàng )新領(lǐng)軍人才;
2013,國家自然科學(xué)二等獎“干細胞多能性與重編程機理研究”(第三完成人)。
獲獎及榮譽(yù):
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1, Xueting Xu, …, Baoming Qin. (2021) The mTORC1-eIF4F axis controls paused pluripotency. EMBO Reports, e53081. DOI: 10.15252/embr.202153081.
2, Yinghua Huang, Hui Zhang, …, Miguel A. Esteban*, Baoming Qin*. (2020) JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. Nature Communications, 11: 5061-5076. (*co-corresponding author)
3, Zicong Liu, …, Gongcheng Hu*, Baoming Qin*. (2019) Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology. Stem Cell Research, 41: 101638-101641. (*co-corresponding author)
4, Lulu Wang, …, Baoming Qin. (2019) mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. The FEBS Journal, DOI: 10.1111/febs.15024.
5, Yasong Wu, Yuan Li, …, Baoming Qin*, Duanqing Pei*. (2015) Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nature Cell Biology, 17: 715-725. (*co-corresponding author)
6, Xichen Bao, …, Baoming Qin*, Miguel Angel Esteban*. (2013) MicroRNAs in somatic cell reprogramming. Current Opinion in Cell Biology, 25: 208-214. (*co-corresponding author)
7, Jianbin Su, …, Baoming Qin. (2013) Roles of small molecules in somatic cell reprogramming. Acta Pharmacologica Sinica, 34: 719-724.
8, Miguel Angel Esteban#, Tao Wang#, Baoming Qin#, …, Duanqing Pei. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 6 (1): 1-9. (#co-first author; cover story)
9, Baoming Qin, …, Duanqing Pei. (2006) Sorting nexin 10 induces giant vacuoles in mammalian cells. Journal of Biological Chemistry, 281 (48): 36891-36896. (cover story)
10, Baoming Qin, …, Duanqing Pei. (2005) Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy. Cell Research, 15 (3): 212-217.
11, Ping Cui#, Baoming Qin#, …, Duanqing Pei. (2004) Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Experimental Cell Research, 293: 154-163. (#co-first author)