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    專(zhuān)家人才

    • 姓名: 秦寶明
    • 性別: 男
    • 職稱(chēng): 研究員
    • 學(xué)歷: 博士
    • 電話(huà): 
    • 傳真: 
    • 電子郵件: qin_baoming@gibh.ac.cn
    • 通訊地址 廣州市開(kāi)源大道190號

      簡(jiǎn)歷:

    • 教育:
      2007.9-2010.6,博士,細胞生物學(xué),中國科學(xué)院廣州生物醫藥與健康研究院
      1994.9-1998.6,學(xué)士,生物化學(xué)與分子生物學(xué),北京大學(xué)生命科學(xué)學(xué)院
      工作:
      2013.9-現在,研究員,中科院廣州生物醫藥與健康研究院
      2010.7-2013.8,副研究員,中科院廣州生物醫藥與健康研究院
      2004.9-2007.8,助理研究員,中科院廣州生物醫藥與健康研究院 

      研究領(lǐng)域:

    • 代謝與細胞命運實(shí)驗室:

      衰老主要通路mTORC1-線(xiàn)粒體在干細胞穩態(tài)維持和命運決定中的作用和機制;

      胚胎發(fā)育早期不同命運干細胞的轉錄和表觀(guān)遺傳調控機理。

      承擔科研項目情況:

      社會(huì )任職:

      獲獎及榮譽(yù):

    • 2019年,廣東省自然科學(xué)一等獎“尿液誘導多能干細胞技術(shù)及體細胞重編程機制”(第二完成人);廣州開(kāi)發(fā)區“黃埔人才”;

      2017,中國科學(xué)院杰出科技成就獎“干細胞多能性與重編程機理研究集體”(主要完成人);

      2016,廣東省“特支計劃”科技創(chuàng )新領(lǐng)軍人才;

      2013,國家自然科學(xué)二等獎“干細胞多能性與重編程機理研究”(第三完成人)。

      代表論著(zhù):

    • 1, Xueting Xu, …, Baoming Qin. (2021) The mTORC1-eIF4F axis controls paused pluripotency. EMBO Reports, e53081. DOI: 10.15252/embr.202153081.

      2, Yinghua Huang, Hui Zhang, …, Miguel A. Esteban*, Baoming Qin*. (2020) JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. Nature Communications, 11: 5061-5076. (*co-corresponding author)

      3, Zicong Liu, …, Gongcheng Hu*, Baoming Qin*. (2019) Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology. Stem Cell Research, 41: 101638-101641. (*co-corresponding author)

      4, Lulu Wang, …, Baoming Qin. (2019) mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. The FEBS Journal, DOI: 10.1111/febs.15024.

      5, Yasong Wu, Yuan Li, …, Baoming Qin*, Duanqing Pei*. (2015) Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nature Cell Biology, 17: 715-725. (*co-corresponding author)

      6, Xichen Bao, …, Baoming Qin*, Miguel Angel Esteban*. (2013) MicroRNAs in somatic cell reprogramming. Current Opinion in Cell Biology, 25: 208-214. (*co-corresponding author)

      7, Jianbin Su, …, Baoming Qin. (2013) Roles of small molecules in somatic cell reprogramming. Acta Pharmacologica Sinica, 34: 719-724.

      8, Miguel Angel Esteban#, Tao Wang#, Baoming Qin#, …, Duanqing Pei. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 6 (1): 1-9. (#co-first author; cover story)

      9, Baoming Qin, …, Duanqing Pei. (2006) Sorting nexin 10 induces giant vacuoles in mammalian cells. Journal of Biological Chemistry, 281 (48): 36891-36896. (cover story)

      10, Baoming Qin, …, Duanqing Pei. (2005) Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy. Cell Research, 15 (3): 212-217.

      11, Ping Cui#, Baoming Qin#, …, Duanqing Pei. (2004) Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Experimental Cell Research, 293: 154-163. (#co-first author)