亚洲免费女色在线,久久综合给合久久狠狠狠…,亚洲一区二区成人,免费人成网555www
    





    
    

    

    
    
    
    
    

    

    

    


    
    
    
        
    
            
            
            
            
    
                
       首頁(yè) >> 資源庫 >> 中文 >> 專(zhuān)家人才
    
                
    

                
    專(zhuān)家人才
    

                
    
                    
    
                        
      
                            
    • 姓名： 姚紅杰
      • 
                            
    • 性別： 男
      • 
                            
    • 職稱(chēng)： 研究員
      • 
                            
    • 學(xué)歷： 博士
      • 
                            
    • 電話(huà)： 020-32015279
      • 
                            
    • 傳真： 
      • 
                            
    • 電子郵件: yao_hongjie@@gibh.ac.cn
      • 
                            
    • 通訊地址 廣州市科學(xué)城開(kāi)源大道190號
      • 
                        
    
                    
    
                    
    
                        					

                    
    
                    
    
                    
    
                        
      
                            
      簡(jiǎn)歷：
      
                            
    • 

      

      

      姚紅杰，博士，研究員，健康研究中心主任，國家杰出青年科學(xué)基金獲得者，國家重點(diǎn)研發(fā)計劃項目負責人。2005年畢業(yè)于中國科學(xué)院植物研究所，獲理學(xué)博士學(xué)位。從2005年11月出國留學(xué)，先后在美國賓夕法尼亞州立大學(xué)、美國國立衛生研究院等機構從事博士后研究工作，主要從事表觀(guān)遺傳及染色質(zhì)組織對基因表達調控的機理研究。2011年10月加入中國科學(xué)院廣州生物醫藥與健康研究院，建立“干細胞表觀(guān)遺傳調控”研究組，任課題組長(cháng)、研究員、博士生導師。2012年獲得中科院人才計劃擇優(yōu)支持（終期評估優(yōu)秀）。作為課題負責人先后承擔來(lái)自國家自然科學(xué)基金、國家重點(diǎn)研發(fā)計劃、中科院戰略性先導科技專(zhuān)項、廣東省重點(diǎn)領(lǐng)域研發(fā)計劃項目的資助；參加科技部干細胞重大科學(xué)研究計劃（973）項目。近年來(lái)，相關(guān)研究成果以通訊作者分別發(fā)表在Cell Stem Cell, Science Advances, Nature Communications, Nucleic Acids Research, Cell Reports等學(xué)術(shù)刊物上。
      

      

      

      • 
                        
    
                        
      
                            
      研究領(lǐng)域：
      
                            
    • 

      

      1）干細胞命運調控的表觀(guān)遺傳機制
      

      2）人類(lèi)疾病的干細胞模型、動(dòng)物模型的建立和致病機制研究
      

      3）腫瘤發(fā)生發(fā)展的表觀(guān) 遺傳調控機制
      

      

      • 
                        
    
                        
      
                            
      承擔科研項目情況：
      
                            
    • 

      

      

      國家杰出青年科學(xué)基金項目
      

      國家科技部重點(diǎn)研發(fā)計劃
      

      國家自然科學(xué)基金聯(lián)合基金重點(diǎn)項目
      

      中科院器官重建與制造先導專(zhuān)項
      

      廣東省重點(diǎn)領(lǐng)域研發(fā)計劃項目
      

      

      • 
                        
    
                        
      
                            
      社會(huì )任職：
      
                            
    • 

      

      

      中國生物化學(xué)與分子生物學(xué)學(xué)會(huì )基因專(zhuān)業(yè)委員會(huì ) 委員
      

      中國生物化學(xué)與分子生物學(xué)學(xué)會(huì )核糖核酸專(zhuān)業(yè)委員會(huì ) 委員
      

      中國生物物理學(xué)會(huì )衰老生物學(xué)分會(huì ) 委員
      

      Scientific Reports, 編委
      

      

      

      • 
                        
    
                        
      
                            
      獲獎及榮譽(yù)：
      
                            
    • 

      

      

      2021 國家重點(diǎn)研發(fā)計劃首席科學(xué)家
      

      2021 廣州市黃埔區杰出人才
      

      2020 臻溪生命科學(xué)優(yōu)秀教育工作者
      

      2019 國家杰出青年科學(xué)基金獲得者
      

      2018 中國科學(xué)院廣州教育基地“優(yōu)秀研究生導師”
      

      2017 中國科學(xué)院院級人才計劃終期評估優(yōu)秀
      

      2016 中國科學(xué)院廣州分院“優(yōu)秀青年科學(xué)家”
      

      2012 中國科學(xué)院院級人才計劃入選者
      

      2010 美國國立衛生研究院“研究員卓越研究獎” 
      

      2004 中國科學(xué)院院長(cháng)獎學(xué)金優(yōu)秀獎
      

      2001 山西省“興晉挑戰杯”高校青年師生學(xué)術(shù)科技作品競賽優(yōu)秀獎
      

      

      

      • 
                        
    
                        
      
                            
      代表論著(zhù)：
      
                            
    • 

      

      1)        Dong X, Guo R, Ji T, Zhang J, Xu J, Li Y, Sheng Y, Wang Y, Fang K, Wen Y, Liu B, Hu G, Deng H, Yao H*. YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency.  Nucleic Acids Research 2022. Apr 15: gkac230. doi: 10.1093/nar/gkac230. (Breakthrough Article)
      

      2)        Song Y, Liang Z, Zhang J, Hu G, Wang J, Li Y, Guo R, Dong X, Babarinde IA, Ping W, Sheng YL, Li H, Chen Z, Gao M, Chen Y, Shan G, Zhang MQ, Shan G, Hutchins AP, Fu X-D*, Yao H*. CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Reports 2022. Apr 5;39(1):110626.
      

      3)        Hu G, Dong X, Gong S, Song Y, Hutchins AP, Yao H*. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Research 2020. 48(17): 9606-9620.
      

      4)        Li Y, Song Y, Xu W, Li Q, Wang X, Li K,Wang J, Liu Z, Velychko S, Ye R, Xia Q, Wang L, Guo R, Dong X, Zheng Z, Dai Y, Li H, Yao M, Xue Y, Scho？ler HR, Sun Q*, Yao H*. R-Loops Coordinate with SOX2 in Regulating Reprogramming to Pluripotency. Science Advances 2020. 6(24): eaba0777. 
      

      5)        Li J, Huang K, Hu G, Babarinde IA, Li Y, Dong X, Chen Y-S, Shang L, Guo W, Wang J, Chen Z, Hutchins AP, Yang Y-G, Yao H*. An Alternative CTCF Isoform Antagonizes Canonical CTCF Occupancy and Changes Chromatin Architecture to Promote Apoptosis. Nature Communications 2019. 10(1): 1535. doi.org/10.1038/s41467-019-08949-w. (Highlighted by Nature Communications Editor). 
      

      6)        Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, Huang K, Lai P, Shi G, Sun H, Wang H, Yao H*. PCGF5 is Required for Neural Differentiation of Embryonic Stem Cells. Nature Communications 2018. 9(1):1463. doi: 10.1038/s41467-018-03781-0. 
      

      7)        Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H*. RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-based Repression of RYBP and its PRC1-dependent and -independent Functions. Cell Stem Cell 2017. 20(4):462-477. (Previewed by Cell Stem Cell). 
      

      8)        Li W, Shang L, Huang K, Li J, Wang Z, Yao H*. Identification of Critical Base Pairs Required for CTCF Binding in Motif M1 and M2. Protein & Cell 2017. 8: 544-549. 
      

      9)        Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G*, Yao H*. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation 2021 Mar 5:e13000. doi: 10.1111/cpr.13000. 
      

      10)     Song Y, Hu G, Jia J, Yao M, Wang X, Lu W, Hutchins AP, Chen J, Ozato K, Yao H*. DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner. Front Mol Biosci. 2020. 7: 618088. 
      

      11)     Ping W, Hu J, Hu G, Li H, Song Y, Xia Q, Yao M, Gong S, Jiang C*, Yao H*. Genome-wide DNA Methylation Analysis Reveals that Mouse Chemical iPSCs Have Closer Epigenetic Features to mESCs than OSKM-integrated-iPSCs. Cell Death & Disease 2018. 9(2):187. 
      

      12)     Shan Y, Liang Z, Xing Q, Zhang T, Wang B, Tian S, Huang W, Zhang Y, Yao J, Zhu Y, Huang K, Liu Y, Wang X, Chen Q, Zhang J, Shang B, Li S, Shi X, Liao B, Zhang C, Lai K, Zhong X, Shu X, Wang J, Yao H, Chen J, Pei D, Pan G*. PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not na？ve ESCs. Nature Communications 2017. 8(1):672. doi: 10.1038/s41467-017-00668-4.
      

      13)     Peng X, So KK, He L, Zhao Y, Zhou J, Li Y, Yao M, Xu B, Zhang S, Yao H, Hu P, Sun H*, Wang H*. MyoD and FoxO3 mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Nucleic Acids Research 2017. 45: 8785-8805.
      

      14)     Huang K, Zhang X, Shi J, Yao M, Lin J, Li J, Liu H, Li H, Shi G, Wang Z, Zhang B, Chen J, Pan G, Jiang C, Pei D*, Yao H*. Dynamically Reorganized Chromatin is the Key for the Reprogramming of Somatic Cells to Pluripotent Cells. Scientific Reports 2015. 5:17691. doi: 10.1038/srep17691. 
      

      15)     Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J*, Pei D*. The Oncogene c-Jun Impedes Somatic Cell Reprogramming. Nature Cell Biology 2015. 17:856-67. 
      

      16)     Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA*. Transcriptional Pause Release is a Rate-limiting Step for Somatic Cell Reprogramming. Cell Stem Cell 2014. 15: 574-588. 
      

      17)     Huang K, Jia J, Wu C, Yao M, Li M, Jin J, Jiang C, Cai Y, Pei D, Pan G*, Yao H*. Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding factor (CTCF) is Negatively Regulated by the Condensin Complex. Journal of Biological Chemistry 2013. 288: 26067-26077. 
      

      18)     Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, Wang X, Hu X, Gu T, Zhou Z, Liu J, Liu J, Wu H, Mao S, Mo K, Li Y, Lai K, Qi J, Yao H, Pan G, Xu GL*, Pei D*. Vitamin C Modulates TET1 Function during Somatic Cell Reprogramming. Nature Genetics 2013. 45:1504-1509. 
      

      19)     Hu J＃, Yao H＃, Gan F, Tokarski A, Wang Y*. Interaction of OKL38 and p53 in Regulating Mitochondrial Structure and Function. PLoS One 2012. 7: e43362. (＃Equal contribution). 
      

      20)     Pan G, Wang T, Yao H, Pei D*. Somatic Cell Reprogramming for Regenerative Medicine: SCNT vs. iPS Cells. Bioessays 2012. 34: 472-476. 
      

      21)     Ghirlando R, Giles K, Gowher H, Xiao T, Xu Z, Yao H, Felsenfeld G*. Chromatin Domains, Insulators, and the Regulation of Gene Expression. Biochim Biophys Acta 2012. 1819: 644-651. 
      

      22)     Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero R, Felsenfeld G*. Mediation of CTCF Transcriptional Insulation by DEAD-box RNA-binding Protein p68 and Steroid Receptor RNA Activator SRA. Genes & Development 2010. 24: 2543-2555. 
      

      23)     Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, Wang Y*. Coordination of PAD4 and HDAC2 in the Regulation of p53-target Gene Expression. Oncogene 2010. 29: 3153-3162. 
      

      24)     Yao H, Li P, Venters B, Zheng S, Thompson P, Pugh BF, Wang Y*. Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis. Journal of Biological Chemistry 2008. 283: 20060-20068. 
      

      25)     Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, Tamura T, Natsume H, Yao H, Ozato K*. The Bromodomain Protein Brd4 Stimulates G1 Gene Transcription and Promotes Progression to S Phase. Journal of Biological Chemistry 2008. 283: 9040-9048. 
      

      26)     Tian S*, Yao H, Deng X, Xu X, Qin G, Chan Z. Characterization and Expression of beta-1, 3-Glucanase Genes in Jujube Fruit Induced by the Microbial Biocontrol Agent Cryptococcus laurentii. Phytopathology 2007. 97: 260-268. 
      

      27)     Yao H, Tian S*. Effects of a Biocontrol Agent and Methyl Jasmonate on Postharvest Diseases of Peach Fruit and the Possible Mechanisms Involved. Journal of Applied Microbiology 2005. 98: 941-950. 
      

      28)     Yao H, Tian S*. Effects of Pre- and Postharvest Application of Salicylic Acid or Methyl Jasmonate on Inducing Disease Resistance of Sweet Cherry Fruit in Storage. Postharvest Biology and Technology 2005. 35: 253-262. 
      

      29)     Yao H, Tian S*. Wang Y. Sodium Bicarbonate Enhances Biocontrol Efficacy of Yeasts on Fungal Spoilage of Pears. International Journal of Food Microbiology 2004. 93: 297-304. 
      

      

      •