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       首頁(yè) >> 資源庫 >> 中文 >> 專(zhuān)家人才
    
                
    

                
    專(zhuān)家人才
    

                
    
                    
    
                        
      
                            
    • 姓名： 王金勇
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    • 性別： 男
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    • 職稱(chēng)： 研究員
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    • 學(xué)歷： 博士
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    • 電話(huà)： 
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    • 傳真： 
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    • 電子郵件: wang_jinyong(AT)gibh.ac.cn
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    • 通訊地址 廣州市科學(xué)城開(kāi)源大道190號
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      簡(jiǎn)歷：
      
                            
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      課題組簡(jiǎn)介
      

      王金勇，研究員，血液與免疫細胞再生研究組組長(cháng)，國家自然科學(xué)基金杰出青年科學(xué)基金（2019醫學(xué)部）獲得者，中國科學(xué)院大學(xué)博士生導師。他的研究團隊旨在結合體內誘導譜系重編程、體外誘導干細胞分化、造血骨髓微環(huán)境原位重建等多途徑探索血液及免疫細胞再生與生理功能重建。其研究團隊長(cháng)期聚焦“抗白血病免疫細胞再生與白血病骨髓微環(huán)境原位修復”研究，在T細胞再生等領(lǐng)域取得一系列原創(chuàng  )技術(shù)突破，擁有多項發(fā)明專(zhuān)利 
      

       
      

      個(gè)人經(jīng)歷
      

      2012年3月至今：中國科學(xué)院廣州生物醫藥與健康研究院，研究員
      

      2007年9月-2012年2月：美國威斯康星醫學(xué)院、威斯康星大學(xué)麥迪遜醫學(xué)與公共衛生學(xué)院，博士后
      

      2006年8月-2007年8月：中國農業(yè)科學(xué)院上海獸醫研究所， 博士后
      

      2001年-2006年：浙江大學(xué)， 博士
      

      1997年-2001年：萊陽(yáng)農學(xué)院，學(xué)士
      

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      研究領(lǐng)域：
      
                            
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      血液與免疫細胞再生
      

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      承擔科研項目情況：
      
                            
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      社會(huì )任職：
      
                            
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      獲獎及榮譽(yù)：
      
                            
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      獲國家杰出青年科學(xué)基金資助
      

      國家重點(diǎn)研發(fā)計劃項目首席科學(xué)家
      

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      代表論著(zhù)：
      
                            
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      1. Wang, T., Xia, C., Weng, Q., Wang, K., Dong, Y., Hao, S., Dong, F., Liu, X., Liu, L., Geng, Y., Guan, Y., Du, J., Cheng, T., Cheng, H., Wang, J. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica, DOI: 10.3324/haematol.2019.239186.
      

      2. Wang, T., Lv, C., Hu, F., Liu, L., Wang, J. (2020) Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells. Blood Science 2, 79-88.
      

      3. Guo, R., Wu, H., Du, J., Wang, J. (2020) T cell regeneration: an update on progress and challenges. Blood Science 2, 22-26.
      

      4. Hu, F., Huang, D., Luo, Y., Zhou, P., LV, C., Wang, K., Weng, Q., Liu, X., Guan Y., Geng, Y., Du, J., Chen J., Wang, J., and Wu, H. (2020) Haematopoietic lineage-converted T cells carrying tumour associated antigen-recognizing TCRs effectively kill tumour cells. Journal for ImmunoTherapy of Cancer, DOI: 10.1136/jitc-2019-000498.
      

      5. LV, C., Chen, S., Hu, F., Huang, D., Wang, T., Du, J., Wang, J., and Wu, H. (2020) Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo. Cellular & Molecular Immunology, DOI: 10.1038/s41423-020-0429-4.
      

      6. Xia, C., Wang, T., Cheng, H., Dong, Y., Weng, Q., Sun, G., Zhou, P., Wang, K., Liu, X., Geng, Y., Ma, S., Hao, S., Xu, L., Guan, Y., Du, J., Du, X., Li, Y., Zhu, X., Shi, Y., Xu, S., Wang, D., Cheng, T., and Wang, J. (2020) Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia, 34(9):2375-2383.
      

      7. Guo, R., Hu, F., Weng, Q., Lv, C., Wu, H., Liu, L., Li, Z., Zeng, Y., Bai, Z., Zhang, M., Liu, Y., Liu, X., Xia, C., Wang, T., Zhou, P., Wang, K., Dong, Y., Luo, Y., Zhang, X., Guan, Y., Geng, Y., Du, J., Li, Y., Lan, Y., Chen, J., Liu, B., and Wang, J. (2020) Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors. Cell Research 30, 21-33.
      

      8. Weng, Q., Hu, F., Zhang, M., Dong, Y., Lv, C., Wang, Y., Liu, X., Wang, J. (2018) A protocol for generating induced T cells by reprogramming B cells in vivo. Cell Regeneration 7, 7-15.
      

      9. Zhang, M., Dong, Y., Hu, F., Yang, D., Zhao, Q., Lv, C., Wang, Y., Xia, C., Weng, Q., Liu, X., Li, C., Zhou, P., Wang, T., Guan, Y., Guo, R., Liu, L., Geng, Y., Wu, H., Du, J., Hu, Z., Xu, S., Chen, J., He, A., Liu, B., Wang, D., Yang, Y. G., and Wang, J. (2018) Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nat Immunology 19, 279-290.
      

      10. Li, X., Xia, C., Wang, T., Liu, L., Zhao, Q., Yang, D., Hu, F., Zhang, M., Huang, K., Geng, Y., Zheng, Y., Guan, Y., Wu, H., Chen, X., Pan, G., Chen, J., Du, J., and Wang, J. (2017) Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Research 21, 32-39. 
      

      11. Chen, X., Zhao, Q., Li, C., Geng, Y., Huang, K., Zhang, J., Wang, X., Yang, J., Wang, T., Xia, C., Liu, X., Meng, M., Yang, D., Zheng, Y., Du, J., Zhang, X., Chen, J., Pan, G., and Wang, J. (2015) OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo. Stem Cell Research 15, 395-402.
      

      12. Yang, D., Zhang, X., Dong, Y., Liu, X., Wang, T., Wang, X., Geng, Y., Fang, S., Zheng, Y., Chen, X., Chen, J., Pan, G., and Wang, J. (2015) Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo. Cell Cycle 14, 612-620. 
      

      13. Wang, T., Li, C., Xia, C., Dong, Y., Yang, D., Geng, Y., Cai, J., Zhang, J., Zhang, X., and Wang, J. (2015) Oncogenic NRAS hyper-activates multiple pathways in human cord blood stem/progenitor cells and promotes myelomonocytic proliferation in vivo. Am J Transl Res 7, 1963-1973. 
      

      14. Wang, J., Kong, G., Liu, Y., Du, J., Chang, Y. I., Tey, S. R., Zhang, X., Ranheim, E. A., Saba-El-Leil, M. K., Meloche, S., Damnernsawad, A., Zhang, J., and Zhang, J. (2013) Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood 121, 5203-5207. 
      

      15. Wang, J., Liu, Y., Li, Z., Wang, Z., Tan, L. X., Ryu, M. J., Meline, B., Du, J., Young, K. H., Ranheim, E., Chang, Q., and Zhang, J. (2011) Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood 118, 368-379. 
      

      16. Wang, J., Liu, Y., Li, Z., Du, J., Ryu, M. J., Taylor, P. R., Fleming, M. D., Young, K. H., Pitot, H., and Zhang, J. (2010) Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 116, 5991-6002.
      

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