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    專(zhuān)家人才

    • 姓名: Alexander Strunnikov
    • 性別: 男
    • 職稱(chēng): 研究員
    • 學(xué)歷: 博士
    • 電話(huà): 
    • 傳真: 
    • 電子郵件: alex@gibh.org
    • 通訊地址 廣州市科學(xué)城開(kāi)源大道190號

      簡(jiǎn)歷:

    • 2009-至今:美國國家衛生研究院過(guò)敏和傳染病研究所免疫病理學(xué)實(shí)驗室?? 高級科學(xué)家

      1996-2008:美國國家衛生研究院基因調控與發(fā)育實(shí)驗室? 研究員

      1992-1996:? 華盛頓卡內基研究所胚胎系D. Koshland博士實(shí)驗室? 博士后

      1989-1991:俄羅斯科學(xué)院細胞研究所V. Larionov博士有絲分裂基因學(xué)實(shí)驗室研究生

      1989:BioTechnika Ltd. 和 匈牙利生物研究中心? 訪(fǎng)問(wèn)學(xué)者

      1987-1988:俄羅斯科學(xué)院細胞研究所染色體穩定與細胞工程實(shí)驗室? 研究實(shí)習員

      1985-1986:圣彼得堡流感研究所生物技術(shù)研究中心 基因工程系? 實(shí)習和技術(shù)員

      ??????????????????????????????????????????????????????????????

      2009-至今:攻讀馬里蘭州大學(xué)生物技術(shù)和生物信息學(xué)碩士 (非全日制,2012年畢業(yè))

      2010-2011:美國癌癥研究所癌癥研究中心“臨床腫瘤學(xué)轉化研究”繼續教育課程(兩個(gè)學(xué)期)

      2008-2009:美國衛生研究所非學(xué)位課程:逆轉錄酶病毒,動(dòng)物實(shí)驗操作程序,芯片技術(shù),高通量篩選數據分析,Unix原理,高級SAS, 平行計算及其他。

      1995: Cold Spring Harbor 實(shí)驗室課程:蛋白純化與特征

      1987-1991:俄羅斯科學(xué)院細胞研究所博士學(xué)位

      ?????????? 導師:Dr. V. Larionov.

      ????? ?????論文題目:控制染色體在有絲分裂中分布的相關(guān)基因研究

      1979-1984: 圣彼得堡大學(xué)生物與遺傳學(xué)學(xué)士學(xué)位(優(yōu)秀)

      主修:生物學(xué)和遺傳學(xué), 兼修:生物教學(xué)

      研究領(lǐng)域:

      承擔科研項目情況:

      社會(huì )任職:

      獲獎及榮譽(yù):

    • 1999:提名為美國衛生研究院院長(cháng)發(fā)言人之一

      2001:霍德休斯醫學(xué)研究所導師資格

      2006:為美國政府服務(wù)十年榮譽(yù)證書(shū)

      職業(yè)協(xié)會(huì )會(huì )員資格:????????????????????????????

      美國遺傳協(xié)會(huì )

      美國生物細胞協(xié)會(huì )

      美國科學(xué)促進(jìn)會(huì )

      參加的項目評審小組:?????????????????????????????????????????????

      2005: 美國國家衛生研究院細胞核動(dòng)態(tài)和運輸特別研究小組

      美國國家科學(xué)基金會(huì )

      瑞士國家科學(xué)基金會(huì )

      奧地利Fonds zur Forderung der Wisscenschaftlishen Forsung,

      ?

      意大利癌癥研究協(xié)會(huì )

      英國國際癌癥研究協(xié)會(huì )

      英國威康信托基金會(huì )

      新加坡科學(xué)技術(shù)研究會(huì )

      新加坡生物醫藥研究理事會(huì )

      新西蘭皇家馬斯登基金會(huì )

      參加的演講與學(xué)術(shù)報告????????????????????????????????????????????????

      應邀在美國國內及國際會(huì )議和學(xué)術(shù)報告會(huì )上多次發(fā)表演講:

      1994年 美國舊金山細胞生物學(xué)學(xué)會(huì )年度會(huì )議

      1995年 新墨西哥州陶斯細胞周期國際會(huì )議

      1997年 新墨西哥州圣達菲細胞核組織和功能會(huì )議

      1999年 美國國家衛生研究院學(xué)術(shù)報告演講人

      2000年 費城美國人類(lèi)遺傳學(xué)會(huì )第50屆會(huì )議

      2000年 美國實(shí)驗生物學(xué)聯(lián)合會(huì )舉辦的關(guān)于染色體組織和復制會(huì )議

      2002年 馬爾堡大學(xué)學(xué)術(shù)報告會(huì )

      2002年 英國醫學(xué)研究理事會(huì )學(xué)術(shù)報告會(huì )

      2002年 法國巴斯德研究院學(xué)術(shù)報告會(huì )

      2005年 日本岡崎機制擴大國際會(huì )議

      2005年 荷蘭奈梅亨分子科學(xué)中心學(xué)術(shù)報告會(huì )

      2005年 美國吉斯通DNA復制會(huì )議

      2007年 日本靜岡市細胞周期國際會(huì )議

      2007年 日本東京科技學(xué)院學(xué)術(shù)報告會(huì )

      2008年 西班牙巴塞羅那癌癥預測和個(gè)體化醫學(xué)中心國際研討會(huì )

      2009年 日本沖繩理工學(xué)院學(xué)術(shù)報告會(huì )

      2010年 西班牙發(fā)展生物學(xué)安達盧西亞中心學(xué)術(shù)報告會(huì )

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      代表論著(zhù):

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      * E. Pugacheva, T. Suzuki, S. Pack, N. Kosaka-Suzuki, J. Yoon, A. Vostrov, E. Barsov, A.Strunnikov, H. Morse III, D. Loukinov, V. Lobanenkov. (2010) The structural complexity of the human BORIS gene in gametogenesis and cancer. PLoS ONE 5:e13872

      * A. Samoshkin, A. Arnaoutov, L.E.T. Jansen, I. Ouispenski, L. Dye, T. Karpova, J. McNally, M.Dasso, Don W. Cleveland and A. Strunnikov. (2009) Human condensin function is essential for centromeric chromatin assembly and sister kinetochore orientation. PLoS ONE 4:e6831

      * S. Dulev, C. de Renty, R. Mehta, I. Minkov, E. Schwob and A. Strunnikov. (2009) Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants. PNAS 106: 14466-14471

      * Y. Takahashi, S. Dulev, X. Liu, N. Hiller, X. Zhao and A. Strunnikov (2008) Cooperation of sumoylated chromosomal proteins in rDNA maintenance. PLoS Genetics 4:e1000215

      * S. Dulev, L. Aragon, and A Strunnikov (2008) Unreplicated DNA in mitosis precludes condensin binding and chromosome condensation in S. cerevisae. Frontiers in Biosciences 13:5838-5846

      * Y. Takahashi and A. Strunnikov (2008) In vivo modeling of polysumoylation uncovers targeting of Topoisomerase II to the nucleolus via optimal level of SUMO modification. Chromosoma 117:189-198

      * B.D. Wang and A. Strunnikov (2008) Transcriptional homogenization of rDNA repeats in the episome-based nucleolus induces genome-wide changes in the chromosomal distribution of condensin. Plasmid 59:45-53

      * V. Yong-Gonzalez, B.D. Wang, P. Butylin, I. Ouspenski and A. Strunnikov (2007) Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids. Genes to Cells 12:1075-1090

      * B. D. Wang, P. Butylin and A. Strunnikov (2006) Condensin function in mitotic nucleolar segregation is regulated by rDNA transcription. Cell Cycle 5:2260-2267

      * Y. Takahashi, V. Yong-Gonzalez, Y. Kikuchi and A. Strunnikov (2006) The SIZ1/SIZ2 control of chromosome transmission fidelity is mediated by their role in sumoylation of topoisomerase II. Genetics 172:783-794

      * B. Quimby, V. Yong-Gonzalez, T. Anan, A. Strunnikov and M. Dasso (2006) The

      promyelocytic leukemia protein (PML) stimulates Sumo conjugation in yeast. Oncogene 25:2999-3005

      * B.D. Wang, D. Eyre, M. Basrai, M. Lichten and A. Strunnikov (2005) Condensin binding at distinct and specific chromosomal sites in the Saccharomyces cerevisiae genome. Molecular and Cellular Biology 25: 7216-7225

      * B. D. Wang, V. Yong-Gonzalez and A. Strunnikov. (2004) Cdc14p/FEAR pathway controls segregation of nucleolus in S. cerevisiae by facilitating condensin targeting to rDNA chromatin in anaphase. Cell Cycle 3:960-967

      * A. Kagansky, L. Freeman, D. Lukyanov, and A. Strunnikov. (2004) Histone-tail independent chromatin-binding activity of recombinant cohesin holocomplex. Journal of Biological Chemistry 279:3382-3388

      * J. Mascarenhas, J. Soppa , A. Strunnikov and P. L. Graumann (2002) Cell cycle dependent localization of two novel prokaryotic chromosome segregation and condensation proteins in Bacillus subtilis that interact with SMC protein. EMBO Journal. 21:3108-3128

      * A. Strunnikov, L. Aravind and E. V. Koonin (2001) Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Genetics.158: 95- 107

      * L. Aragon-Alcaide and A. Strunnikov (2000) Functional dissection of in-vivo interchromosome association in S. cerevisiae. Nature Cell Biology 2: 812-818

      * L. Freeman, L.Aragon-Alcaide and A. Strunnikov (2000) The condensin complex governs chromosome condensation and mitotic transmission of rDNA. Journal of Cell Biology 149: 811-824

      * N. Darwiche, L. A. Freeman , and A. Strunnikov (1999) Characterization of the components of the putative mammalian sister chromatid cohesion complex. Gene. 233:39-47

      * P. L. Graumann, R. Losick, A. V. Strunnikov (1998) Subcellular localization of Bacillus subtilis SMC, a protein involved in chromosome condensation and segregation. Journal of Bacteriology 180:5749-5755

      * V. Guacci, D. Koshland, A.V. Strunnikov (1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S.cerevisiae. Cell 91:47-57

      A. Strunnikov, E. Hogan and D. Koshland (1995) SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation defines a subgroup within the SMCfamily. Genes and Development 9: 87-599

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      A. Strunnikov, J. Kingsbury and D. Koshland (1995) CEP3 encodes a centromere protein of Saccharomyces cerevisiae. Journal of Cell Biology 128:749-760

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      A. Strunnikov, V. Larionov and D. Koshland (1993) SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family. Journal of Cell Biology 123:1635-1648

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      V. Guacci, A. Yamamoto, A. Strunnikov, J. Kingsbury, E. Hogan, P. Meluh and D. Koshland (1993) Structure and function of chromosomes in mitosis of budding yeast. In: Cold Spring Harbor Symposia on Quantitative Biology /DNA and Chromosomes. 58:677-685, Cold Spring Harbor, New York

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      V. Larionov, N. Kouprina N., A. Strunnikov and A. Vlasov (1989) A direct selection procedure for isolating yeast mutants with an impaired segregation of artificial minichromosomes. Current Genetics 15:17-26

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      V. Larionov, N. Kouprina, A. Strunnikov, A. Vlasov and V. Pirozhkov (1989) Direct selection procedure for isolation of yeast mutants with impaired segregation of chromosomes. Progress in Clinical and Biological Research, Vol. 138: Mechanisms of chromosome distribution and aneuploidy, 303-316; Alan R. Liss, Inc., New York

      評論和圖書(shū)章節??????????????????????????????????????????????????????

      * A. Strunnikov (2010) One-hit wonders of genomic instability. Cell Division 5: 15

      * Y. Takahashi, Iwase M, A. Strunnikov, Y. Kikuchi (2008) Cytoplasmic sumoylation by PIAStype Siz1-SUMO ligase. Cell Cycle. 7:1738-1744

      * A. Strunnikov (2006) SMC complexes in bacterial chromosome condensation and segregation. Plasmid 55:135-144

      * A. Strunnikov. (2005) A case of selfish nucleolar segregation. Cell Cycle 4: 113-117

      * A. Strunnikov. (2003) Condensin and biological role of chromosome condensation. Progress in Cell Cycle Research 5: 361-368

      * P. Meluh and A. V. Strunnikov (2002) Beyond the ABC of CKC and SCC. Do centromeres orchestrate sister chromatid cohesion or vice versa? European Journal of Biochemistry. 269:2300–2314

      * A. V. Strunnikov, R. Jessberger (1999) SMC Proteins: Conserved molecular properties for multiple biological functions. European Journal of Biochemistry. 263:6-13

      * A. V. Strunnikov (1998) SMC proteins and chromosome structure. Trends in Cell Biology. 8:454-459

      * D. Koshland and, A. Strunnikov (1996) Mitotic chromosome condensation. Annual Reviews of Cell and Developmental Biology 12:305-333

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