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專(zhuān)家人才
- 姓名： 王濤
- 性別： 男
- 職稱(chēng)： 研究員
- 學(xué)歷： 博士
- 電話(huà)：
- 傳真：
- 電子郵件: wang_tao@gibh.ac.cn
- 通訊地址 廣州市科學(xué)城開(kāi)源大道190號
2017.3- Guangzhou Institutes of Biomedicine and Health PI
2015.4-2017.3 Yale University, Yale Stem Cell Center Associated Research Scientist
2012.6-2015.4 The University of North Carolina-Chapel Hill, Postdoctoral Associate
2010.7-2012.6 Guangzhou Institutes of Biomedicine and health, Research Scientist
2006.9-2010.7 Guangzhou Institutes of Biomedicine and health, Research Scientist, Ph.D student
2002.7-2005.9 NanKai University, Master Student
1998.7-2002.9 Yangtze University, Bachelor Student
簡(jiǎn)歷：
We are interested in ageing biology、aging related diseases and stem cell regeneration. Cell aging (Cell Senescence) cause tissue dysfunction/degeneration. Cumulative researches uncovered distinct factors that can trigger senescence, such as telomere erosion、DNA damage、mitochondrial dysfunction and epigenetic alteration. One of our aims is to search for new proteins or factors maintaining genome integrity and stability, to this end, we perform whole genome wide screening and manipulate these factors to delay senescence even aging.
Emerging reports suggested that elimination of senescent cell in mouse can delay aging or restore tissue function in some extent. We are also exploiting vulnerabilities of senescent cell to identify novel pathways to selective killing of old cell.
Organoids culture and stem cell differentiation provide powerful tools to investigate human disease mechanisms, we want to combine organoid culture and gene editing to model aging related diseases with purpose of invention of cure methods.
研究領(lǐng)域：
承擔科研項目情況：
社會(huì )任職：
獲獎及榮譽(yù)：
1.Wu, T.P., T. Wang, M.G. Seetin, Y. Lai, S. Zhu, K. Lin, Y. Liu, S.D. Byrum, S.G. Mackintosh, M. Zhong, A. Tackett, G. Wang, L.S. Hon, G. Fang, J.A. Swenberg, and A.Z. Xiao. DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature. 2016. 532:329-333.
2.Esteban, M.A. *, Wang, T. *, Qin, B. *, Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., Chen, K., Li, Y., Liu, X., Xu, J., Zhang, S., Li, F., He, W., Labuda, K., Song, Y., Peterbauer, A., Wolbank, S., Redl, H., Zhong, M., Cai, D., Zeng, L., and Pei, D. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 2010. 6(1): 71-79. (*Contributed equally)
3.Wang, T., Chen, K., Zeng, X., Yang, J., Wu, Y., Shi, X., Qin, B., Zeng, L., Esteban, M.A., Pan, G., and Pei, D. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell, 2011. 9(6): 575-587.
5.Qin, D., Gan, Y., Shao, K., Wang, H., Li, W., Wang, T., He, W., Xu, J., Zhang, Y., Kou, Z., Zeng, L., Sheng, G., Esteban, M.A., Gao, S., and Pei, D. Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors. J Biol Chem, 2008. 283(48): 33730-33735.