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    專(zhuān)家人才

    • 姓名: 陳可實(shí)
    • 性別: 男
    • 職稱(chēng): 研究員
    • 學(xué)歷: 博士
    • 電話(huà): 020-32015340
    • 傳真: 
    • 電子郵件: chen_keshi@gibh.ac.cn
    • 通訊地址 廣州市開(kāi)源大道190號

      簡(jiǎn)歷:

    • 2004-?。玻埃埃?/span>年,中國科學(xué)技術(shù)大學(xué),生物技術(shù),學(xué)士,

      2008 –?。玻埃保?/span>年,中國科學(xué)院大學(xué),生物化學(xué)和分子生物學(xué),博士,

      2013 –?。玻埃保?/span>年,中國科學(xué)院廣州生物醫藥與健康研究院,助理研究員

      2017 –?。玻埃玻?/span>年,中國科學(xué)院廣州生物醫藥與健康研究院,副研究員

      2023 – 今,中國科學(xué)院廣州生物醫藥與健康研究院,研究員

      研究領(lǐng)域:

    • 多能干細胞命運轉換的機制研究

      承擔科研項目情況:

    • 1,中國科學(xué)院青年創(chuàng )新促進(jìn)會(huì )優(yōu)秀會(huì )員

      2,廣州市科學(xué)技術(shù)局基礎研究計劃

      3,國家自然科學(xué)基金青年項目

      4,廣東省公益研究與能力建設項目

      5,廣東省自然科學(xué)基金博士啟動(dòng)項目

      社會(huì )任職:

    •  

      獲獎及榮譽(yù):

    • 2021年度中國科學(xué)院青年創(chuàng )新促進(jìn)會(huì )優(yōu)秀會(huì )員

      2020年度廣東省自然科學(xué)一等獎(5/15

      2017年度中國科學(xué)院杰出科技成就獎(主要完成者)

      代表論著(zhù):

    • 1. Guangsuo Xing, Zichao Liu, Luyuan Huang, … Duanqing Pei*, Xingguo Liu*, Keshi Chen*. MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, Cell Death & Differentiation, 2022, 29(5):1042-1054

      2. Yi Wu#, Keshi Chen#, Linpeng Li#, Zhihong Hao#, … Xingguo Liu*. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, Cell Death & Differentiation, 2022, 29(11):2316-2331

      3. Linpeng Li#, Keshi Chen#, Yi Wu#, … Xingguo Liu*. Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes, Journal of Genetics and Genomics, 2022, 49(4):279-286

      4. Linpeng Li#, Keshi Chen#, Tianyu Wang#, Yi Wu#, … Xingguo Liu*. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism, 2020, 2(9): 882-892

      5Keshi Chen, Qi Long, Guangsuo Xing, … Duanqing Pei *; Xingguo Liu *, Heterochromatin loosening by Oct4 linker facilitates Klf4’s binding and initiates iPSC reprogramming. EMBO Journal, 2020, 39(1):e99165

      6. Yi Wu #, Keshi Chen#, Guangsuo Xing, … Xingguo Liu*, Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Science Advances, 2019, 5(11):eaax7525

      7. Linpeng Li#, Keshi Chen#, Yi Wu, … Xingguo Liu*. Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, Cell Death & Disease, 2017, 8(10):e3107,

      8. Keshi Chen#, Qi Long#, Tao Wang, … Xingguo Liu*, Duanqing Pei*. Gadd45a is a heterochramatin relaxer that enhances iPS cell generation, EMBO Reports, 2016, 17(11):1641-1656

      9.Yi Wu#, Keshi Chen#, Xiyin Liu, … Xingguo Liu*. Srebp-1 interacts with c-Myc to enhance somatic cell reprogramming, Stem Cells, 2016, 34(1):83-92

      10. Danyun Zhao, Yi Wu, Keshi Chen*. Tbx3 isofroms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, Biochem Biophys Res Commun, 2014, 444(3):411-414