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專(zhuān)家人才
- 姓名： 熊曉犁
- 性別： 男
- 職稱(chēng)： 研究員
- 學(xué)歷： 博士
- 電話(huà)：
- 傳真：
- 電子郵件: xiong_xiaoli@gibh.ac.cn
- 通訊地址 廣州市黃埔區開(kāi)源大道190號
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熊曉犁，博士，研究員，廣東省珠江人才計劃青年拔尖人才，英國微生物學(xué)會(huì )會(huì )員。在英國布里斯托大學(xué)生物化學(xué)系/細胞和分子醫學(xué)系分別獲得生物化學(xué)與生物技術(shù)學(xué)士學(xué)位和病理學(xué)與微生物學(xué)博士學(xué)位。熊曉犁研究員先后在英國MRC National Institute for Medical Research (現Francis Crick Institute) 病毒學(xué)系 Sir John Skehel研究組，美國華盛頓大學(xué)（西雅圖）生物化學(xué)系，英國MRC Laboratory of Molecular Biology結構生物學(xué)系從事病原微生物致病機理的研究。2020年9月加入中國科學(xué)院廣州生物醫藥與健康研究院。
近10年來(lái)熊曉犁研究員研究了H5N1, H7N9, H10N8流感病毒的跨種傳播機理（Xiong et. al. Nature 2013a, Xiong et. al. Nature 2013b, Xiong et. al. Virology 2014, Vachieri*, Xiong.* et. al. Nature 2014）, 流感病毒的裝配機制 （Peukes*, Xiong*# et. al. Nature 2020）。冠狀病毒的入侵機制 (Xiong et. al. J. Virology 2018, Walls*, Xiong* et. al. Cell 2019), 新型冠狀病毒表面抗原S蛋白的穩定化（Xiong*# et. al. Nat. Struct. Mol. Biol. 2020）等科學(xué)問(wèn)題。研究團隊旨在運用結構生物學(xué)與生物化學(xué)方法探明病原微生物的致病機理，并在理解其致病機理的基礎上開(kāi)發(fā)干預手段。
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獲獎及榮譽(yù)：
1. Xiong, X.*#, Qu, K.*, Ciazynska, K.A., Hosmillo, M., Carter, A.P., Ebrahimi, S., Ke, Z., Scheres, S.H.W., Bergamaschi, L., Grice, G.L., Zhang, Y., The CITIID-NIHR COVID-19 Bioresource, Nathan, J.A., Baker, S., James, L.C., Helen, E., Goodfellow, I., Doffinger, R., and Briggs, J.A.G. # (2020). A thermostable, closed, SARS-CoV-2 spike protein trimer. Nat. Struct. Mol. Biol.
2. Peukes, J.*, Xiong, X.*#, Erlendsson, S., Qu, K., Wan, W., Leslie, J., Schraidt, O., Kummer, S., Freund, S.M.V., Kraeusslich H-G., Briggs, J.A.G #. (2020). The native structure of the assembled matrix protein 1 of influenza A virus. Nature.
3. Zunlong Ke, Oton, J., Qu, K., Cortese, M., Zila, V., McKeane, L., Nakane, T., Zivanov, J., Neufeldt2, C.J., Lu, J.M., Peukes, J., Xiong, X., Kraeusslich, H-G., Scheres, S.H.W., Bartenschlager, R., Briggs, J.A.G. (2020). Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions. Nature.
4. Mlcochova, P., Collier, D., Ritchie, A. V, Assennato, S.M., Hosmillo, M., Goel, N., Meng, B., Chatterji, K., Mendoza, V., Temperton, N., Kiss, L., Ciazyns, K.A., Xiong, X., Briggs, J.A.G., Nathan, J., Mescia, F., Zhang, H., Barmpounakis, P., Demeris, N., et al. (2020). Combined point of care SARS-CoV-2 nucleic acid and antibody testing in suspected moderate to severe COVID-19 disease. Cell Reports Medicine.
5. Zheng, A., Sun, W., Xiong, X., Freyn, A.W., Peukes, J., Stromeier, S., Nachbagauer, R., Briggs, J.A.G., Krammer, F., and Palese, P. (2020). Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals. J. Virol. .
6. Gamblin, S.J., Vachieri, S.G., Xiong, X., Zhang, J., Martin, S.R., and Skehel, J.J. (2020). Hemagglutinin Structure and Activities. Cold Spring Harb. Perspect. Med. a038638.
7. Walls, A. C.*, Xiong, X.*, Park, Y, Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Dai, M., Zambon, M., Rey, F. A., Corti, D., Veesler, D. (2019). Unexpected receptor functional mimicry elucidates activation of coronavirus fusion. Cell 176,1026-1039
8. Xiong, X.,Tortorici, M. A., Snijder, J., Yoshioka, C., Walls, A. C., Li, W., McGuire, A. T., Rey, F. A., Bosch, B., Veesler, D., (2018) Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections. J. Virology, 92, e01628-17
9. Walls, A. C, Tortorici, M. A, Snijder, J, Xiong, X, Bosch, B. J, Rey, F. A and Veesler, D., (2017) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Proc Natl Acad Sci. U S A 114:11157-11162.
10. Xiong, X., Corti, D., Liu, J., Pinna, D., Foglierini, M., Calder, L.J., Martin, S. R., Lin, Y.P., Walker, P. A., Collins, P. J., Moine, I., Suguitan Jr., A.L., Santos, C., Temperton, N.J., Subbarao, K., Lanzavecchia, A., Gamblin, S.J., Skehel, J. J., (2015) Structures of complexes formed by H5 influenza haemagglutinin with a potent broadly neutralizing human monoclonal antibody. Proc Natl Acad Sci U S A 112, 9430-9435.
11. Xiong, X. McCauley, J.W., Steinhauer, D.A. (2014). Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range. Curr Top Microbiol Immunol 385, 63-91
12. Vachieri, S.G.*, Xiong, X.*, Collins, P.J., Walker, P.A., Martin, S.R., Haire, L.F., Zhang, Y., McCauley, J.W., Gamblin, S.J., and Skehel, J.J. (2014). Receptor binding by H10 influenza viruses. Nature 511, 475-477.
13. Xiong, X.*, Xiao, H.*, Martin, S. R., Coombs, P. J., Liu, J., Collins, P. J., Vachieri, S. G., Walker, P. A., Lin, Y. P., McCauley, J. W., Gamblin, S. J. & Skehel, J. J. (2014). Enhanced human receptor binding by H5 haemagglutinins. Virology, 456-457, 179-187.
14. Xiong, X., Tuzikov, A., Coombs, P. J., Martin, S., Walker, P. A., Gamblin, S. J., Bovin, N. & Skehel, J. J. (2013). Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus. Virus Res, 178, 12-4.
15. Xiong, X., Martin, S. R., Haire, L. F., Wharton, S. A., Daniels, R. S., Bennett, M. S., McCauley, J. W., Collins, P. J., Walker, P. A., Skehel, J. J. & Gamblin, S. J. (2013). Receptor binding by an H7N9 influenza virus from humans. Nature, 499, 496-9.
16. Xiong, X.*, Coombs, P. J.*, Martin, S. R.*, Liu, J., Xiao, H., McCauley, J. W., Locher, K., Walker, P. A., Collins, P. J., Kawaoka, Y., Skehel, J. J. & Gamblin, S. J. (2013). Receptor binding by a ferret-transmissible H5 avian influenza virus. Nature, 497, 392-6.
18. Xiong, X., Bromley, E. H., Oelschlaeger, P., Woolfson, D. N. & Spencer, J. (2011). Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a gram-negative bacterium. Nucleic Acids Res, 39, 3917-27.
l 共同第一作者。#共同通訊作者。