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教育經(jīng)歷

2011.9-20115.7 中國科學(xué)院廣州生物醫藥與健康研究院，博士

2006.9-2010.6 中國科學(xué)技術(shù)大學(xué) 生命科學(xué)學(xué)院，碩士

2002.9-2006.6 合肥工業(yè)大學(xué) 生物技術(shù)系，學(xué)士

工作經(jīng)歷

2015.7-至今 中國科學(xué)院廣州生物醫藥與健康研究院，助理研究員、副研究員

2010.7-2011.8中國科學(xué)院廣州生物醫藥與健康研究院，研究實(shí)習員

新陳代謝是所有生物學(xué)過(guò)程的核心，包括免疫細胞的分化、增殖和免疫功能的維持；代謝紊亂會(huì )導致免疫功能障礙和疾病進(jìn)展。

(1)   肝臟脂質(zhì)組裝、分泌的分子機制；

(2)   脂質(zhì)穩態(tài)對免疫細胞功能和免疫重塑的影響；

(3)   分泌型磷脂酶A2調控呼吸道病毒感染及免疫反應。

(1)   國家自然科學(xué)基金面上項目 (項目負責人，2020年)

(2)   廣東省自然科學(xué)基金面上項目 (項目負責人，2020年、2019年)

(3)   “十三五”國家科技重大專(zhuān)項 (任務(wù)負責人，2018年)

(4)   國家重點(diǎn)研發(fā)計劃 (任務(wù)負責人，2017年)

(# 共同第一作者，* 共同通訊作者)

1.      Qihong Yan^#, Pingchao Li^#, Xianmiao Ye^#, Xiaohan Huang^#, Bo Feng, Tianxing Ji, Zhilong Chen, Feng Li, Yudi Zhang, Kun Luo, Fengjuan Chen, Xiaoneng Mo, Jianhua Wang, Liqiang Feng, Fengyu Hu, Chunliang Lei,Linbing Qu*, Ling Chen*. Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients.Journal of Immunology, 2021, 206: 2146-2159.

2.       Qihong Yan^#, Ping He^#, Xiaohan Huang^#, Kun Luo, Yudi Zhang, Haisu Yi, Qian Wang, Feng Li, Ruitian Hou, Xiaodi Fan, Pingchao Li, Xinglong Liu, Huan Liang, Yijun Deng, Zhaoming Chen, Yunfei Chen, Xiaoneng Mo, Liqiang Feng, Xiaoli Xiong, Song Li, Jian Han, Linbing Qu*, Xuefeng Niu*, Ling Chen*. Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients. Emerging Microbes & Infections, 2021, 10: 1097-1111.

3.       Shengnan Zhang, Changhua Yi, Fan Zhang, Weiqi Pan, Chufang Li, Jiaojiao Peng, Qian Wang, Xinglong Liu, Min Wu, Xianmiao Ye, Pingchao Li, Qihong Yan, Wenjing Guo, Xuefeng Niu, Liqiang Feng, Linbing Qu*, Ling Chen*. Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and is effective in preventing maternal to fetus Zika virus transmission. Antiviral Research, 2019, 169: 104547.

4.       Longhui Chen^#, Min Wu^#, Shengnan Zhang, Wenjuan Tan, Min Guan, Liqiang Feng, Chen    Chen, Jun Tao, Ling Chen*, Linbing Qu*. Estrogen-related receptor gamma regulates hepatic triglyceride metabolism through phospholipase A2 G12B. FASEB Journal, 2019, 33(7), 7942-7952.  

5.       Xuefeng Niu^#, Lingzhai Zhao^#, Linbing Qu, Zhipeng Yao, Fan Zhang, Qihong Yan, Shengnan Zhang, Renshan Liang, Peihai Chen, Jia Luo, Wei Xu, Huibin Lv, Xinglong Liu, Hui Lei, Changhua Yi, Pingchao Li, Qian Wang, Yang Wang, Lei Yu, Xiaoyan Zhang, L. Aubrey Bryan, Edgar Davidson. Benjamin Doranz, Liqiang Feng, Weiqi Pan*, Fuchun Zhang*, Ling Chen*. Convalescent patient derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model. Emerging Microbes & Infections, 2019, 8:749-760.

6.       Xinglong Liu^#, Linbing Qu^#, Xianmiao Ye^#, Changhua Yi, Xuehua Zheng, Mingli Hao, Wan Su, Zhipeng Yao, Peihai Chen, Shengnan Zhang, Yupeng Feng, Qian Wang, Qihong Yan, Pingchao Li, Heying Li, Feng Li, Weiqi Pan, Xuefeng Niu, Ruian Xu, Liqiang Feng*, Ling Chen*. Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein. npj Vaccines, 2018, 3:29-36.

7.       Feng Li^#,*, Peirong Wang^#, Linbing Qu^#, Changhua Yi, Fuchun Zhang, Xiaoping Tang, Liguo Zhang, Ling Chen*. AXL is not essential for Zika virus infection in the mouse brain. Emerging Microbes & Infections, 2017, 6: e16-e17.

8.       Hui Zhi, Linbing Qu, Fang Wu, Ling Chen*, Jun Tao*. Group IIE Secretory Phospholipase A2 Regulates Lipolysis in Adipocytes. Obesity, 2015, 23: 760-768.

9.       Xinlei Li^#, Hanfang Jiang^#, Linbing Qu, Wenxia Yao, Hua Cai, Ling Chen, Tao Peng*. Hepatocyte Nuclear Factor 4α and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus. Journal of Virology, 2014, 88: 612-627.

10.    Min Guan^#, Linbing Qu^#, Wenjuan Tan, Ling Chen*, Chi-wai Wong*. Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A2 GXIIB. Hepatology, 2011, 53: 458-464.