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專(zhuān)家人才
- 姓名： 董良
- 性別： 男
- 職稱(chēng)： 副研究員
- 學(xué)歷： 博士
- 電話(huà)：
- 傳真：
- 電子郵件: dong_liang@gibh.ac.cn
- 通訊地址 廣州市黃埔區開(kāi)源大道190號
2005.09-2009.07 安徽大學(xué) 生物工程 學(xué)士?
2009.09-2015.07 中國科學(xué)院上海生物化學(xué)與細胞生物學(xué)研究所 發(fā)育生物學(xué) 博士?
2015.08-2017.08 中山大學(xué)-深圳市第二人民醫院 博士后
2017.08-2019.08 香港城市大學(xué) 博士后
2019.09-2022.12 廣州醫科大學(xué)附屬廣州市婦女兒童醫療中心 兒科研究所 研究主管（副研究員）?
2023.02至今 中國科學(xué)院廣州生物醫藥與健康研究院 細胞譜系與發(fā)育研究中心 副研究員?
簡(jiǎn)歷：
肺損傷修復過(guò)程中細胞譜系分化的作用機制研究
腫瘤發(fā)生與免疫調控作用機制的研究
研究領(lǐng)域：
1. 國家自然科學(xué)基金青年項目（2018） 項目負責人
2. 廣東省科技計劃項目（2017） 項目負責人
3. 中國博士后科學(xué)基金面上項目（2015） 項目負責人
4. 廣州市科技計劃項目（2022） 項目負責人
5. 深圳市科技計劃項目（2017） 項目負責人
6. 廣州醫科大學(xué)科研強基項目（2023） 項目負責人
7. 廣州市高層次衛生人才引進(jìn)培養項目（2022） 項目負責人
承擔科研項目情況：
社會(huì )任職：
獲獎及榮譽(yù)：
1. Liang Dong, Wenwen Luo, Skaldin Maksym, Simon C. Robson, Andrey V. Zavialov. Adenosine deaminase 2 regulates the activation of the Toll-like receptor 9 in response to nucleic acids. Frontiers of Medicine 2024, DOI: 10.1007/s11684-024-1067-5
2. Wenwen Luo*, Liang Dong*, Fenghong Chen*, Wenbin Lei*, Liya He, Qing Zhou, Thierry Lamy and Andrey V. Zavialov. ELISA based assays to measure adenosine deaminases concentration in serum and saliva for the diagnosis of ADA2 deficiency and cancer. Frontiers in Immunology 2022;13:928438.? (*Indicates equal contribution)?
3. Liang Dong, Xiaoming Lyu, Oluwasijibomi Damola Faleti, Ming-Liang He. The special stemness functions of Tbx3 in stem cells and cancer development. Seminars in Cancer Biology, 57(2019)105–110.?
4. Liang Dong, Qi Dong, Ying Chen, Yichen Li, Bao Zhang, Fanghang Zhou, Xiaoming Lyu, George G Chen, Paul Lai, Hsiang-fu Kung, Ming-Liang He. Novel HDAC5 interacting motifs of Tbx3 are essential for suppressing E-cadherin expression and promoting metastasis of hepatocellular carcinoma. Signal Transduction and Targeted Therapy, 2018, 3, 22.?
5. Liang Dong, Fan Lin, Wanjun Wu, Yuchen Liu and Weiren Huang. Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway. International Journal of Medical Sciences, 2018, 15(6): 645-652.?
6. Liang Dong, Fan Lin, Wanjun Wu, Weiren Huang and Zhiming Cai. Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell. Journal of Cancer, 2016, 7(14): 2132-2138.?
7. Fan Lin*, Liang Dong*, Weiming Wang, Yuchen Liu, Weiren Huang and Zhiming Cai. An Efficient Light-Inducible P53 Expression System for Inhibiting Proliferation of Bladder Cancer Cell. International Journal of Biological Sciences, 2016, 12(10): 1273-1278. (*Indicates equal contribution)?
8. Liang Dong, Jinhui Li, Hongling Huang, Meng-Xin Yin, Jinjin Xu, Peixue Li, Yi Lu, Wenqing Wu, Hang Yang, Yun Zhao and Lei Zhang. Growth Suppressor Lingerer Regulates bantam microRNA to Restrict Organ Size. Journal of Molecular Cell Biology, 2015, 7(5), 415–428.?
9. Meng Zhang*, Liang Dong*, Shi Jiao*, Zhubing Shi*, Zhen Zhang, Wenqing Zhang, Guoguang Liu, Cuicui Chen, Miao Feng, Wenjia Wang, Yun Zhao, Mark Greene, Lei Zhang, and Zhaocai Zhou. Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases. Structure, 2013, 21(4): 680-688. (*Indicates equal contribution)?
10. Dacai Xu, Jiawen Wu, Liang Dong, Wenwen Luo, Lanying Li, Daolin Tang, Jinbao Liu. Serpinc1 acts as a tumor suppressor in hepatocellular carcinoma through inducing apoptosis and blocking macrophage polarization in an ubiquitin-proteasome manner. Frontiers in Oncology, 2021, 11:738607.?
11. Chao Wang, Meng-Xin Yin, Wei Wu, Liang Dong, Shimin Wang, Yi Lu, Jinjin Xu, Wenqing Wu, Sheng Li, Yun Zhao, Lei Zhang. Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration. Cell Discovery. 2016; 2: 16006.?
12. Hong-Ling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao, Xin-Yuan Liu, Lei Zhang. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS Biology. 2013; 11: e1001620.
13. Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai Zhou, Lei Zhang. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. Journal of Biological Chemistry. 2012; 287: 5784-96.